搜索结果: 'EasySep Direct'

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Online Immunology Journal Club: New Strategies to Target Macrophages in Cancer

发布日期: 08/10/2020
45:33:00

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SARS-CoV-2 Viral Diversity: Causes, Consequences, and Opportunities

发布日期: 08/21/2020
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Human Peripheral Blood Leukopaks Flyer

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品牌：

EasySep

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产品名：
科学海报
Immunomagnetic Cell Isolation of Human Gamma-Delta T Cells from PBMC

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Conference：

ECI 2012

产品号#：

19255

19255RF

18000

产品名：

EasySep™人Gamma/Delta T细胞分选试剂盒

RoboSep™ 人Gamma/Delta T细胞分选试剂盒

EasySep™磁极
科学海报
Cell Isolation of Human CD4+ Memory T Cells By Column-Free Immunomagnetic Cell Separation

产品类型：

Conference：

ECI 2006

产品号#：

19157

19157RF

21000

20155

20119

18000

产品名：

EasySep™人记忆CD4+ T细胞富集试剂盒

RoboSep™ 人记忆CD4 T细胞富集试剂盒含滤芯吸头

RoboSep™- S

RoboSep™分选管套装（9个塑料管）

RoboSep™ 吸头组件抛光剂

EasySep™磁极
科学海报
Method for Negative Enrichment of Monocytes from Mouse Blood and Bone Marrow

产品类型：

Conference：

AAI 2009

产品号#：

21000

20155

20119

19761

19761RF

产品名：

RoboSep™- S

RoboSep™分选管套装（9个塑料管）

RoboSep™ 吸头组件抛光剂
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Antigen Processing and Presentation Overview of the mechanisms by which antigens are processed and presented to T cells
2:37

视频
Immunology Profiles - Kyle Burrows

发布日期: 05/03/2016
科学海报
Positive Selection of PE- or Biotin-Conjugated Antibody Labeled Cells with Releasable Rapidspheres™

产品类型：

Conference：

AAI 2017

产品号#：

17654

17656

17655

17653

产品名：

EasySep™ Release人PE正选试剂盒

EasySep™ Release小鼠PE正选试剂盒

EasySep™ Release小鼠Biotin正选试剂盒

EasySep™ Release人Biotin正选试剂盒
Henault J et al. (FEB 2016) Nature Immunology 17 2 196--203

Self-reactive IgE exacerbates interferon responses associated with autoimmunity.

Canonically,immunoglobulin E (IgE) mediates allergic immune responses by triggering mast cells and basophils to release histamine and type 2 helper cytokines. Here we found that in human systemic lupus erythematosus (SLE),IgE antibodies specific for double-stranded DNA (dsDNA) activated plasmacytoid dendritic cells (pDCs),a type of cell of the immune system linked to viral defense,which led to the secretion of substantial amounts of interferon-α (IFN-α). The concentration of dsDNA-specific IgE found in patient serum correlated with disease severity and greatly potentiated pDC function by triggering phagocytosis via the high-affinity FcɛRI receptor for IgE,followed by Toll-like receptor 9 (TLR9)-mediated sensing of DNA in phagosomes. Our findings expand the known pathogenic mechanisms of IgE-mediated inflammation beyond those found in allergy and demonstrate that IgE can trigger interferon responses capable of exacerbating self-destructive autoimmune responses. View Publication

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产品号#：

17953

17953RF

100-0710

产品名：

EasySep™人CD8+ T细胞分选试剂盒

RoboSep™ 人CD8+ T细胞分选试剂盒

EasySep™人CD8+ T细胞分选试剂盒
Weisel FJ et al. (JAN 2016) Immunity 44 1 116--30

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells.

There is little insight into or agreement about the signals that control differentiation of memory B cells (MBCs) and long-lived plasma cells (LLPCs). By performing BrdU pulse-labeling studies,we found that MBC formation preceded the formation of LLPCs in an adoptive transfer immunization system,which allowed for a synchronized Ag-specific response with homogeneous Ag-receptor,yet at natural precursor frequencies. We confirmed these observations in wild-type (WT) mice and extended them with germinal center (GC) disruption experiments and variable region gene sequencing. We thus show that the GC response undergoes a temporal switch in its output as it matures,revealing that the reaction engenders both MBC subsets with different immune effector function and,ultimately,LLPCs at largely separate points in time. These data demonstrate the kinetics of the formation of the cells that provide stable humoral immunity and therefore have implications for autoimmunity,for vaccine development,and for understanding long-term pathogen resistance. View Publication

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产品号#：

19854

19854RF

产品名：

EasySep™小鼠B细胞分选试剂盒

RoboSep™ 小鼠B细胞分选试剂盒
Llibre A et al. (MAR 2016) Journal of Immunology 196 5 2085--94

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

Germinal centers (GCs) are microanatomical structures critical for the development of high-affinity Abs and B cell memory. They are organized into two zones,light and dark,with coordinated roles,controlled by local signaling. The innate lectin-like transcript 1 (LLT1) is known to be expressed on B cells,but its functional role in the GC reaction has not been explored. In this study,we report high expression of LLT1 on GC-associated B cells,early plasmablasts,and GC-derived lymphomas. LLT1 expression was readily induced via BCR,CD40,and CpG stimulation on B cells. Unexpectedly,we found high expression of the LLT1 ligand,CD161,on follicular dendritic cells. Triggering of LLT1 supported B cell activation,CD83 upregulation,and CXCR4 downregulation. Overall,these data suggest that LLT1-CD161 interactions play a novel and important role in B cell maturation within the GC in humans. View Publication

产品类型：

产品号#：

17954

17954RF

100-0971

产品名：

EasySep™人B细胞分选试剂盒

RoboSep™ 人B细胞分选试剂盒

EasySep™人B细胞分离试剂盒