Highly Characterized Human iPSCs and NPCs for Downstream Differentiation Applications
Reproducible research with human induced pluripotent stem cells (iPSCs) depends on access to thoroughly characterized and quality-controlled cell lines. In this webinar, Drs. Andrew Gaffney and Erin Knock will describe the generation of a standardized induced pluripotent stem cell (iPSC) line. Developed with the upcoming ISSCR Standards Initiative characterization guidelines in mind, this highly characterized line is karyotypically stable, demonstrates trilineage differentiation potential, and expresses undifferentiated cell markers. Further, STEMCELL has developed a highly pure, ready-to-use neural progenitor cell product expressing PAX6 and SOX1 over multiple passages. Dr. Knock will show how these multipotent cells are suitable for customized downstream differentiation to various CNS cell types, such as forebrain neurons, midbrain neurons, and astrocytes. These progenitor cells are the ideal controls for standardizing downstream differentiation protocols, modeling diseases, and developing assays.
Immunology Profiles - Kyle Burrows
Kyle Burrows discusses his research on mucosal immune regulation and innate lymphoid cells, and his cell isolation platform of choice, EasySep™
Introducing EpiCult™-C Medium
This medium is fully defined and BPE-free and it supports robust growth of human luminal epithelial and myoepithelial mammary cells
Madeline Lancaster on Brain Organoids: Modeling Human Brain Development in a Dish
In this webinar, Dr. Madeline Lancaster, who has done groundbreaking work in the development of cerebral organoid technology, discusses the latest developments in cerebral organoids and provides a comparison of different 3D model systems being used for neurological research.
Research in the Lancaster lab focuses on human brain development using cerebral organoids, a new in vitro model system for neurological development and disease research. The laboratory uses these ‘mini-brains’ to study the most fundamental differences between human and other mammalian species’ brain development - essentially, what makes us human. The lab is also studying cellular mechanisms of, and potential therapeutic avenues for, neurodevelopmental disorders such as autism and intellectual disability.
This webinar is just one of the educational resources on neural organoids that we’ve developed to help you navigate this exciting field. Visit the Neural Organoid Information Hub to learn more.
RoboSep™-16 Introduction
Introduction of the the RoboSep™-16 instrument, a fully automated cell isolation platform that performs cell isolations from up to 16 samples
Nature Research Round Table: Pluripotency Tests
Dr. Peter Andrews discusses what the term “pluripotency” means in relation to ES and iPS cells, how the term has evolved, and how to assess pluripotent potential by comparing existing assays. Dr. Andrews is co-director of the Centre for Stem Cell Biology at the University of Sheffield. This presentation and the following Q&A session were moderated by Dr. Ludovic Vallier from the Wellcome Trust Sanger Institute.
This presentation was part of a Round Table series titled “Challenges in Ensuring hPSC Quality”, hosted in partnership with Nature Research. Global experts gathered at the Springer Nature headquarters in London, UK, to tackle some of the most pertinent issues impacting the use of human pluripotent stem cells (hPSCs), ranging from fundamental biology research to therapeutic applications. Explore the full series here.
Note: Some original data from this presentation has been omitted to abide by copyright rules.