技术资料

产品手册
Highway1™: Fast Cell Sorting from Bone Marrow

产品类型：

仪器及软件

品牌：

Highway1
产品手册
Highway1™: High-Speed Enrichment from Blood Cells

产品类型：

仪器及软件

品牌：

Highway1
产品手册
Highway1™: Automated Cell Sorting of PBMCs

产品类型：

仪器及软件

品牌：

Highway1
产品手册
Highway1™: High-Purity Sorting of Bacterially-Infected Cells

产品类型：

仪器及软件

品牌：

Highway1
产品手册
Highway1™: Sorting Cell Subtypes from Murine Melanoma

产品类型：

仪器及软件

品牌：

Highway1
产品手册
Highway1™: Truly Gentle Enrichment Sorting

产品类型：

仪器及软件

品牌：

Highway1
L. Starck et al. ( 2014) The Journal of Immunology 192 206-213

Immunotherapy with TCR-Redirected T Cells: Comparison of TCR-Transduced and TCR-Engineered Hematopoietic Stem Cell-Derived T Cells

Redirecting Ag specificity by transfer of TCR genes into PBLs is an attractive method to generate large numbers of cytotoxic T cells for immunotherapy of cancer and viral diseases. However,transferred TCR chains can pair with endogenous TCR chains,resulting in the formation of mispaired TCR dimers and decreased or unspecific reactivity. TCR gene transfer into hematopoietic stem cells (HSCs) is an alternative to create T cells with desired Ag specificity,because in this case expression of endogenous TCR chains is then less likely owing to allelic exclusion. We generated TCR-transduced T cells from peripheral T cells using the lymphocytic choriomeningitis virus-specific P14 TCR. After transfer of the P14 TCR genes into HSCs and subsequent reconstitution of irradiated mice,TCR-engineered HSC-derived T cells were produced. We then compared the Ag-specific T cell populations with P14 TCR-transgenic T cells for their therapeutic efficiency in three in vivo models. In this study,we demonstrate that TCR-transduced T cells and TCR-engineered HSC-derived T cells are comparable in controlling lymphocytic choriomeningitis virus infection in mice and suppress growth of B16 tumor cells expressing the cognate Ag in a comparable manner. View Publication

产品号#：

18756

18756RF

产品名：

EasySep™小鼠SCA1正选试剂盒

RoboSep™ 小鼠SCA1正选试剂盒含滤芯吸头
产品手册
消除基因组编辑的不确定性

品牌：

ArciTect

发布日期: 11/15/2019
科学海报
Isolation of Mouse CD45 Positive Leukocytes from Tissues
技术公告
Expansion and Differentiation of Hematopoietic Stem and Progenitor Cells into Natural Killer (NK) Cells Using StemSpan™ Medium and Supplements

细胞类型：

NK细胞，造血干祖细胞

发布日期: 05/01/2024
1:02

视频
Cell Isolation in One Spin Using SepMate™ Tubes and RosetteSep™ Cell Separation Reagents

发布日期: 03/22/2018
Wu X et al. (JAN 2018) Cell 172 3 423--438.e25

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Stem cells are highly resistant to viral infection compared to their differentiated progeny; however,the mechanism is mysterious. Here,we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that,conserved across species,stem cells express a subset of genes previously classified as interferon (IFN) stimulated genes (ISGs) but that expression is intrinsic,as stem cells are refractory to interferon. This intrinsic ISG expression varies in a cell-type-specific manner,and many ISGs decrease upon differentiation,at which time cells become IFN responsive,allowing induction of a broad spectrum of ISGs by IFN signaling. Importantly,we show that intrinsically expressed ISGs protect stem cells against viral infection. We demonstrate the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection. These findings have intriguing implications for understanding stem cell biology and the evolution of pathogen resistance. View Publication

产品号#：

02691

04434

04444

05110

05711

05712

05872

05873

18056

18056RF

72052

72054

72302

72304

72307

72308

70039

70039.1

70039.2

70039.3

70039.4

70039.5

70039.6

60062

60062BT

60062FI

60062FI.1

60062PE

60062PE.1

60045

60045AZ

60045AZ.1

60045BT

60045FI

60045FI.1

600

产品名：

StemSpan™CD34+扩增补充（10X）

MethoCult™H4434经典

MethoCult™H4434经典

STEMdiff™定型内胚层检测试剂盒

NeuroCult™ SM1 神经添加物

CHIR99021

CHIR99021

Y-27632（二盐酸盐）

Y-27632（二盐酸盐）

Y-27632（二盐酸盐）

Y-27632（二盐酸盐）

Anti-Human SSEA-4 Antibody, Clone MC-813-70，Biotin

Anti-Human SSEA-4 Antibody, Clone MC-813-70，FITC

抗人SSEA-4抗体, Clone MC-813-70，FITC

Anti-Human SSEA-4 Antibody, Clone MC-813-70，PE

Anti-Human SSEA-4 Antibody, Clone MC-813-70，PE

抗人CD90抗体, 克隆号5E10

抗人CD90抗体，克隆5E10，APC

抗人CD90抗体，克隆5E10，APC

抗人CD90抗体，克隆5E10，Biotin

抗人CD90抗体，克隆5E10，FITC

抗人CD90抗体，克隆5E10，FITC