技术资料

8:00

视频
How to Use the CellPore™ Transfection System

发布日期: 12/04/2024
3:41

视频
Cryopreserve Human Peripheral Blood Mononuclear Cells with CryoStor® CS10

发布日期: 11/22/2024
1:54

视频
CellPore™: For Gentle Intracellular Delivery

发布日期: 10/10/2024
1:49

视频
How to Quickly Thaw Frozen Cells with the ThawStar® CFT2 Automated Thawing System

发布日期: 03/07/2023
产品手册
预富集CD138细胞制备杂交瘤

品牌：

ClonaCell
实验方案
Optimizing Delivery Efficiency with Fluorescent Dextran Using the CellPore™ Transfection System

研究方向：

免疫学，疾病建模，药物发现和毒理检测
6:05

视频
How to Thaw Frozen Human Primary Cells

发布日期: 11/13/2020
技术窍门
Frequently Asked Questions on Primary Cells
3:36

视频
Collaborating to Accelerate COVID-19 Research

发布日期: 05/15/2020
实验方案
How to Thaw Frozen Primary Cells

研究方向：

免疫学，干细胞生物学，疾病建模，药物发现和毒理检测，传染病，癌症研究
Alvarado G and Crowe JE ( 2016) 1442 63--76

Development of human monoclonal antibodies against respiratory syncytial virus using a high efficiency human hybridoma technique.

Human monoclonal antibodies against RSV have high potential for use as prophylaxis or therapeutic molecules,and they also can be used to define the structure of protective epitopes for rational vaccine design. In the past,however,isolation of human monoclonal antibodies was difficult and inefficient. Here,we describe contemporary methods for activation and proliferation of primary human memory B cells followed by cytofusion to non-secreting myeloma cells by dielectrophoresis to generate human hybridomas secreting RSV-specific monoclonal antibodies. We also provide experimental methods for screening human B cell lines to obtain RSV-specific lines,especially lines secreting neutralizing antibodies. View Publication

产品号#：

03800

03801

03802

03803

03804

03805

03806

产品名：

ClonaCell™-HY 杂交瘤试剂盒

ClonaCell™-HY Medium

ClonaCell™-HY Medium

ClonaCell™-HY Medium

ClonaCell™-HY Medium

ClonaCell™-HY Medium

ClonaCell™-HY PEG (融合)
Currie KS et al. (MAY 2014) Journal of medicinal chemistry 57 9 3856--73

Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune,inflammatory,and oncology disease indications. The most advanced Syk inhibitor,R406,1 (or its prodrug form fostamatinib,2),has shown efficacy in multiple therapeutic indications,but its clinical progress has been hampered by dose-limiting adverse effects that have been attributed,at least in part,to the off-target activities of 1. It is expected that a more selective Syk inhibitor would provide a greater therapeutic window. Herein we report the discovery and optimization of a novel series of imidazo[1,2-a]pyrazine Syk inhibitors. This work culminated in the identification of GS-9973,68,a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications. View Publication

产品号#：

70034

70023

70023.1

200-0167

200-0166

产品名：

冻存的人外周血单核细胞

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人外周血单核细胞，冷冻

人外周血单核细胞，冷冻