EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #07980_C
细胞培养添加物
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总览
肝素是一种具有抗凝血特性的粘多糖。它支持成纤维细胞生长因子（FGF）与其受体的结合，并提高了FGF的稳定性。肝素与表皮生长因子（EGF）和FGF一起用于NeuroCult™培养基中，用来培养胚胎大鼠或成人神经干和祖细胞，以及成年小鼠神经干和祖细胞。如需完整说明，请参阅技术手册：使用NeuroCult™进行神经干细胞和祖细胞的体外增殖与分化(Human；文档#28724或小鼠/大鼠；文件#28725)，可通过www.stemcell.com或联系我们获取。肝素溶液也被作为各种其他STEMCELL培养基的添加剂，包括MammoCult™ 人培养基试剂盒（产品号#05620），EpiCult™-B小鼠培养基试剂盒（产品号#05610），和EC-Cult™-XF培养试剂盒（产品号#08000）。
包含
0.2% (2 mg/mL; 360 IU/mL) Heparin sodium salt in phosphate-buffered saline (PBS)
亚型
添加剂
细胞类型
乳腺细胞，神经干/祖细胞，其它细胞系，前列腺细胞
种属
人，大鼠
应用
细胞培养
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
相关材料与文献
技术资料 (3)
文献 (1)
Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro-oncology 2011 SEP
Abstract
Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor. During routine animal studies, we serendipitously observed that fenbendazole, a benzimidazole antihelminthic used to treat pinworm infection, inhibited brain tumor engraftment. Subsequent in vitro and in vivo experiments with benzimidazoles identified mebendazole as the more promising drug for GBM therapy. In GBM cell lines, mebendazole displayed cytotoxicity, with half-maximal inhibitory concentrations ranging from 0.1 to 0.3 µM. Mebendazole disrupted microtubule formation in GBM cells, and in vitro activity was correlated with reduced tubulin polymerization. Subsequently, we showed that mebendazole significantly extended mean survival up to 63% in syngeneic and xenograft orthotopic mouse glioma models. Mebendazole has been approved by the US Food and Drug Administration for parasitic infections, has a long track-record of safe human use, and was effective in our animal models with doses documented as safe in humans. Our findings indicate that mebendazole is a possible novel anti-brain tumor therapeutic that could be further tested in clinical trials.
更多信息
| 种属 | Human, Rat |
|---|---|
| Contains | 0.2% (2 mg/mL; 360 IU/mL) Heparin sodium salt in phosphate-buffered saline (PBS) |
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