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抗人CD184（CXCR4）抗体，克隆12G5

小鼠单克隆IgG2a抗体，抗人、恒河猴、食蟹猴CD184（CXCR4）
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产品号 #60089_C

小鼠单克隆IgG2a抗体，抗人、恒河猴、食蟹猴CD184（CXCR4）

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

12G5 抗体可识别 CD184（又称 CXCR4 或 fusin），该蛋白是一种约 45 kDa 的七次跨膜 G 蛋白偶联受体，广泛表达于多种细胞表面，包括 T 细胞、B 细胞、树突状细胞、单核细胞、巨噬细胞、粒细胞、血小板、内皮细胞、上皮细胞、星形胶质细胞和神经元。CD184 至少有两种亚型，由可变剪接的 mRNA 转录产生。其配体包括 CXC 趋化因子 SDF-1 和泛素。CD184 在趋化反应、B 细胞淋巴生成、髓系细胞生成、心脏发育、血管生成及神经引导等过程中发挥重要功能。它还作为某些 HIV-1 T 细胞嗜性分离株感染的共受体，以及 HIV-2 在不依赖 CD4 的情况下感染细胞的替代受体，而这些功能可被 12G5 抗体结合后阻断。该抗体还可部分抑制 SDF-1 诱导的趋化作用和钙离子内流。在分化研究中，CD184 常与其他标志物（如 CD117）联合使用，以监测定型内胚层的出现。

亚型
一抗
 
靶抗原
CD184 (CXCR4)
 
别名
C-X-C 趋化因子受体4型，CXCR4，fusin，HM89，HUMSTR，LAP3，LCR1，LESTR，NPYY3R，NPY3R，SDF-1 receptor，WHIM
 
活性物种
African Green Monkey，Baboon，Chimpanzee，Cynomolgus，人，Rhesus，Sooty Mangabey
 
偶联
APC，Biotin 或 生物素，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
内胚层，PSC衍生，多能干细胞
 
种属
人，非人灵长类
 
应用
CyTOF，流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化
 
研究领域
免疫，干细胞生物学
 
克隆
12G5
 
基因编号
7852
 
同种型
IgG2a，kappa
 

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实验数据

Data for APC-Conjugated

Figure 1. Data for APC-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, APC (filled histogram) or Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173, APC (Catalog #60071AZ) (solid line histogram).

Data for Biotin-Conjugated

Figure 2. Data for Biotin-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, Biotin, followed by streptavidin (SAV) APC (filled histogram), or Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173, Biotin (Catalog #60071BT), followed by SAV APC (solid line histogram).

Data for PE-Conjugated

Figure 3. Data for PE-Conjugated

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, PE (filled histogram) or Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173, PE (Catalog #60071PE) (solid line histogram). (B) Flow cytometry analysis of human embryonic stem (ES) cells following differentiation to definitive endoderm using the STEMdiff™ Definitive Endoderm Kit. Cells were labeled with Anti-Human CD117 (c-Kit) Antibody, Clone 104D2, APC (Catalog #60087AZ) and Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, PE. The emergence of definitive endoderm can be monitored by co-expression of CD117 and CD184. (C) Flow cytometry analysis of human ES cells following differentiation to definitive endoderm using the STEMdiff™ Definitive Endoderm Kit. Cells were labeled with a mouse IgG1, kappa APC isotype control antibody and Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173, PE.

Data for Unconjugated

Figure 4. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, followed by anti-mouse IgG, FITC (filled histogram), or Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173 (Catalog #60071), followed by anti-mouse IgG, FITC (solid line histogram).

产品说明书及文档

请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, Biotin
Catalog #
60089BT
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, PE
Catalog #
60089PE.1, 60089PE
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5
Catalog #
60089
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, APC
Catalog #
60089AZ, 60089AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, Biotin
Catalog #
60089BT
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, PE
Catalog #
60089PE.1, 60089PE
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5
Catalog #
60089
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD184 (CXCR4) Antibody, Clone 12G5, APC
Catalog #
60089AZ, 60089AZ.1
Lot #
All
Language
English

应用领域

本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。

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Workflow Stages

相关材料与文献

技术资料 (2)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

更多信息

更多信息
种属 Human, Non-Human Primate
克隆 12G5
Gene Id 7852
Alternative Names C-X-C chemokine receptor type 4, CXCR4, fusin, HM89, HUMSTR, LAP3, LCR1, LESTR, NPYY3R, NPY3R, SDF-1 receptor, WHIM
同种型/isotype IgG2a, kappa
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