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抗小鼠NK1.1（CD161）抗体，克隆PK136

抗小鼠 NK1.1 (CD161) 的 (C3H x BALB/c) F1 杂交单克隆IgG2a抗体
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产品号 #60103_C

抗小鼠 NK1.1 (CD161) 的 (C3H x BALB/c) F1 杂交单克隆IgG2a抗体

总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

PK136抗体可特异性识别小鼠NK1.1（CD161）。CD161是一种约80 kDa的同型二聚体2型跨膜糖蛋白和C型凝集素受体，在小鼠NK细胞、NK-T细胞以及特定小鼠品系的稀有T细胞和单核细胞的亚群中表达。NK1.1由Klrb1b和Klrb1c基因编码，这两个基因分别编码CD161b和CD161c多肽。CD161b仅在Swiss NIH和SJL小鼠中表达，CD161c在某些品系如C57BL、FVB/N和NZB中表达，但不在A、AKR、BALB/c、CBA/J、C3H、C57BR、C58、DBA/1、DBA/2、NOD、SJL或129中表达。NK1.1在调节多种生理过程方面发挥功能性作用，包括NK细胞的激活和增殖、诱导干扰素-γ的产生以及释放细胞毒性颗粒。IL-12特异性上调其在细胞表面的表达。对于NK1.1-株的NK细胞检测，推荐使用抗小鼠CD49b抗体，克隆DX5（产品号 #60020）。DX5识别CD49b（整合素α2），这是另一种常用的NK细胞标志物。

分类
一抗
 
靶抗原
NK1.1 (CD161)
 
别名
CD161b，CD161c，Klrb1b，Klrb1c，Ly-55，Ly-59，NK-1.1，NKRP1，NKRP1a，NKRP1b
 
反应种属
小鼠
 
偶联
生物素，FITC，PE，未偶联
 
宿主物种
小鼠
 
细胞类型
NK 细胞
 
种属
小鼠
 
应用
细胞分选，CyTOF，删除，流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀
 
研究领域
免疫
 
克隆
PK136
 
Gene ID
17059
 
Isotype
IgG2a, κ轻链
 

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实验数据

Data for Unconjugated

Figure 1. Data for Unconjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, followed by a rat anti-mouse IgG2a antibody, PE and Anti-Mouse CD45 Antibody, Clone 30-F11, APC (Catalog #60030AZ). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC173 (Catalog #60071), followed by a rat anti-mouse IgG2a antibody, PE and Anti-Mouse CD45 Antibody, Clone 30-F11, APC.

Data for Alexa Fluor® 488-Conjugated

Figure 2. Data for Alexa Fluor® 488-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Alexa Fluor® 488 and Anti-Mouse CD45 Antibody, Clone 30-F11, PE (Catalog #60030PE). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173, Alexa Fluor® 488 (Catalog #60071AD) and Anti-Mouse CD45 Antibody, Clone 30-F11, PE.

Data for APC-Conjugated

Figure 3. Data for APC-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, APC and Anti-Mouse CD45 Antibody, Clone 30-F11, PE (Catalog #60030PE). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC173, APC (Catalog #60071AZ) and Anti-Mouse CD45 Antibody, Clone 30-F11, PE.

Data for Biotin-Conjugated

Figure 4. Data for Biotin-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Biotin, followed by streptavidin (SAV) APC and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC (Catalog #60030FI). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC173, Biotin (Catalog #60071BT), followed by SAV APC and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC.

Data for FITC-Conjugated

Figure 5. Data for FITC-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, FITC and Anti-Mouse CD45 Antibody, Clone 30-F11, PE (Catalog #60030PE). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC173, FITC (Catalog #60071FI) and Anti-Mouse CD45 Antibody, Clone 30-F11, PE.

Data for PE-Conjugated

Figure 6. Data for PE-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, PE and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC (Catalog #60030FI). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Mouse IgG2a, kappa Isotype Control Antibody, Clone MOPC-173, PE (Catalog #60071PE) and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC.

Data for PerCP-Cy55-Conjugated

Figure 7. Data for PerCP-Cy55-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, PerCP-Cy5.5 and Anti-Mouse CD45 Antibody, Clone 30-F11, APC (Catalog #60030AZ).

Figure 8. Data for PB-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Pacific Blue™ and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC (Catalog #60030FI). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes (gated on lymphocytes) labeled with a mouse IgG2a, kappa Pacific Blue™ isotype control antibody and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC.

产品说明书及文档

请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Alexa Fluor® 488
Catalog #
60103AD.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, APC
Catalog #
60103AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Biotin
Catalog #
100-0463, 60103BT
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, FITC
Catalog #
60103FI
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Pacific Blue™
Catalog #
60103PB
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, PerCP-Cy5.5
Catalog #
60103PS, 60103PS.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136
Catalog #
100-0459
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Alexa Fluor® 488
Catalog #
60103AD.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, APC
Catalog #
60103AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Biotin
Catalog #
100-0463, 60103BT
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, FITC
Catalog #
60103FI
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, Pacific Blue™
Catalog #
60103PB
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136, PerCP-Cy5.5
Catalog #
60103PS, 60103PS.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136
Catalog #
100-0459
Lot #
All
Language
English

应用领域

本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。

Research Area
Workflow Stages

更多信息

更多信息
种属 Mouse
克隆 PK136
Gene Id 17059
Alternative Names CD161b, CD161c, Klrb1b, Klrb1c, Ly-55, Ly-59, NK-1.1, NKRP1, NKRP1a, NKRP1b
同种型/isotype IgG2a, kappa
法律声明:

Alexa Fluor and Pacific Blue are trademarks of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® or Pacific Blue™ are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. 质量保证:

产品仅供研究使用，不用于针对人或动物的诊断或治疗。 欲获悉更多关于STEMCELL的质控信息，请访问 STEMCELL.CN/COMPLIANCE.
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