In this webinar, Dr. Juergen Knoblich presents data from his preprint, "Cerebral organoid model reveals excessive proliferation of human caudal late interneuron progenitors in Tuberous Sclerosis Complex". 0:00 Studying genetic loss-of-function in animal and human models 5:18 Features of mammalian cortical development 8:59 Features of the cerebral organoid 3D culture model system 13:26 Proof-of-principle: modeling congenital microcephaly using patient-derived organoids 16:19 Modeling Tuberous Sclerosis Complex using stem cell-derived cerebral organoids