This video describes the adaptation of the ClonaCell™-HY semi-solid cloning protocol to a 96-well plate format. This protocol involves screening of hybridoma colonies before expansion, allowing for selective picking and expansion of producing hybridomas. Optimize monoclonal antibody production with the ClonaCell™-HY 96-Well Protocol. Learn more about ClonaCell™-HY Hybridoma Kit > Explore ClonaCell™ media for hybridoma and cell line development >