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(-)-Epigallocatechin Gallate

抗氧化和表观遗传修饰剂;抑制DNA甲基转移酶(DNM)

产品号 #(选择产品)

产品号 #73642_C

抗氧化和表观遗传修饰剂;抑制DNA甲基转移酶(DNM)

总览

(-)-表没食子儿茶素没食子酸酯是绿茶中含量最丰富的多酚儿茶素抗氧化剂(Frémont et al.; Johnson & Maddipati; Miller & Rice-Evans),能够抑制DNA甲基转移酶(DNMTs;IC₅₀=0.21-0.47 μM;Lee et al.)。(-)-表没食子儿茶素没食子酸酯还能抑制氧化低密度脂蛋白的形成(Yoshida et al.),而氧化低密度脂蛋白在心血管疾病和动脉粥样硬化的病理学中起着重要作用(Itabe et al.)。(-)-表没食子儿茶素没食子酸酯还被证实能够抑制过氧亚硝酸盐介导的8-氧代脱氧鸟苷和3-硝基酪氨酸的形成(Fiala et al.)。

分化
·通过诱导破骨细胞样多核细胞而非成骨细胞的细胞死亡来抑制骨吸收(Nakagawa et al.)。

癌症研究
·抑制小鼠异种移植模型中人胰腺癌细胞的生长并诱导其凋亡(Shankar et al., Du et al.)
·导致人表皮样癌细胞系的细胞周期失调和凋亡,可能是通过抑制NF-κB实现(Ahmad et al.)。

别名
EGCG;NVP-XAA723;茶多酚
 
细胞类型
癌细胞及细胞系,心肌细胞,PSC衍生,成骨细胞
 
种属
人,小鼠,非人灵长类,其它细胞系,大鼠
 
应用
分化
 
研究领域
癌症,干细胞生物学
 
CAS 编号
989-51-5
 
化学式
C₂₂H₁₈O₁₁
 
分子量
458.4 克/摩尔
 
纯度
≥98%
 
通路
表观遗传学
 
靶点
DNMT
 

产品说明书及文档

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Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
73644
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
73644
Lot #
All
Language
English

应用领域

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相关材料与文献

文献 (11)

Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Du G-J et al. Nutrients 2012 NOV

Abstract

Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited. In this study, we determined the cancer chemopreventive potentials of 10 representative polyphenols (caffeic acid, CA; gallic acid, GA; catechin, C; epicatechin, EC; gallocatechin, GC; catechin gallate, CG; gallocatechin gallate, GCG; epicatechin gallate, ECG; epigallocatechin, EGC; and epigallocatechin gallate, EGCG), and explored their structure-activity relationship. The effect of the 10 polyphenol compounds on the proliferation of HCT-116 and SW-480 human colorectal cancer cells was evaluated using an MTS assay. Cell cycle distribution and apoptotic effects were analyzed by flow cytometry after staining with propidium iodide (PI)/RNase or annexin V/PI. Among the 10 polyphenols, EGCG showed the most potent antiproliferative effects, and significantly induced cell cycle arrest in the G1 phase and cell apoptosis. When the relationship between chemical structure and anticancer activity was examined, C and EC did not show antiproliferative effects, and GA showed some antiproliferative effects. When C and EC esterified with GA to produce CG and ECG, the antiproliferative effects were increased significantly. A similar relationship was found between EGC and EGCG. The gallic acid group significantly enhanced catechin's anticancer potential. This property could be utilized in future semi-synthesis of flavonoid derivatives to develop novel anticancer agents.
Oxidative modification of LDL: its pathological role in atherosclerosis. Itabe H Clinical reviews in allergy & immunology 2009 AUG

Abstract

Oxidized low-density lipoprotein (OxLDL) is a well-known risk marker for cardiovascular diseases. OxLDL has shown a variety of proatherogenic properties in experiments performed in vitro. In addition, immunological studies using monoclonal antibodies have revealed the occurrence of OxLDL in vivo in atherosclerotic lesions and patients' plasma specimens. Resent clinical studies have indicated the prospective significance of plasma OxLDL measurements; however, the behavior and metabolism of OxLDL in vivo is poorly understood. The mechanism by which LDL is oxidized is not clear, and the modified structures of OxLDL are not yet fully understood, partly because OxLDL is a mixture of heterogeneously modified particles. Here, I discuss the recent studies on oxidative modifications in OxLDL and its clinical and pathological features.
EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Shankar S et al. Frontiers in bioscience : a journal and virtual library 2008 JAN

Abstract

We have shown that epigallocatechin-3-gallate (EGCG), a polyphenolic compound from green tea, inhibits growth and induces apoptosis in human pancreatic cancer cells. However, the preclinical potential of EGCG in a suitable mouse model has not been examined. In this study, we examined the molecular mechanisms by which EGCG inhibited growth, invasion, metastasis and angiogenesis of human pancreatic cancer cells in a xenograft model system. EGCG inhibited viability, capillary tube formation and migration of HUVEC, and these effects were further enhanced in the presence of an ERK inhibitor. In vivo, AsPC-1 xenografted tumors treated with EGCG showed significant reduction in volume, proliferation (Ki-67 and PCNA staining), angiogenesis (vWF, VEGF and CD31) and metastasis (MMP-2, MMP-7, MMP-9 and MMP-12) and induction in apoptosis (TUNEL), caspase-3 activity and growth arrest (p21/WAF1). EGCG also inhibited circulating endothelial growth factor receptor 2 (VEGF-R2) positive endothelial cells derived from xenografted mice. Tumor samples from EGCG treated mice showed significantly reduced ERK activity, and enhanced p38 and JNK activities. Overall, our data suggest that EGCG inhibits pancreatic cancer growth, invasion, metastasis and angiogenesis, and thus could be used for the management of pancreatic cancer prevention and treatment.

更多信息

更多信息
Molecular Weight 458.4 g/mol
种属 Human, Mouse, Non-Human Primate, Other, Rat
Alternative Names EGCG; NVP-XAA723; Tea catechin
Cas Number 989-51-5
Chemical Formula C₂₂H₁₈O₁₁
纯度 ≥ 98%
Target DNMT
Pathway Epigenetic
质量保证:

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