Human pluripotent stem cells (hPSCs) are valuable tools for modeling human disease, as well as a source of differentiated cells for use in regenerative medicine and drug discovery. An essential prerequisite for using hPSCs in medicine is the assurance of genetic stability over long-term maintenance of hPSCs. However, hPSCs can adapt in vitro by acquiring genetic changes that render them less susceptible to differentiation and/or death. The presence of genetic changes in hPSCs coupled with their increased growth rates is reminiscent of the defining features of cancer cells, thus raising concerns about the safe use of hPSCs in clinical applications. Investigating the causes and consequences of genetic changes in hPSCs will help inform approaches to minimize their occurrence in hPSC cultures. View this webinar presentation by Dr. Peter Andrews and Dr. Ivana Barbaric from the University of Sheffield to learn more about the causes and consequences of genetic changes in hPSCs.