EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #100-2070_C
骨形态发生蛋白4，不含动物成分
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总览
骨形态发生蛋白4 （BMP-4）是高度保守的转化生长因子β (TGF-β)超家族的一员。成熟的BMP-4是一种二硫键连接的同源二聚体蛋白，由两个各含 116 个氨基酸残基的亚基组成，是通过蛋白水解去除信号肽和前肽而产生的（Xiao等）。BMP-4 可与细胞表面的I型和II型受体结合。这一结合会导致I型受体的磷酸化，进而使 Smad 蛋白磷酸化，使其作为转录因子发挥作用（Zhang 等）。BMP已被证明是胚胎发生过程中的关键调节因子，并在多种细胞类型的生长和分化中发挥作用，包括胚胎干细胞（ES）细胞、诱导多能干细胞（iPS）细胞、间充质细胞、上皮细胞、造血细胞和神经细胞(Chadwick等；Graham等人；Jones等人；Lengerke等人；Zhang et al.)。本产品不含动物成分（ACF）。
亚型
细胞因子
别名
BMP-2B，BMP2B1，MCOPS6，OFC11，ZYME
细胞类型
内胚层，PSC衍生，造血干/祖细胞，中胚层，PSC衍生，多能干细胞
种属
人
研究领域
癌症，上皮细胞研究，干细胞生物学
制剂类别
Animal Component-Free
纯度
SDS-PAGE 检测：≥ 98%
实验数据
Figure 1. Biological Activity and Molecular Mass of Human Recombinant BMP-4, ACF
(A) The biological activity of Human Recombinant BMP-4, ACF was tested using a BMP4-responsive luciferase reporter assay in transfected HEK293T cells. Firefly luciferase activity is normalized to the control Renilla luciferase activity. The EC50 is defined as the effective concentration of the growth factor at which BMP-4 response is at 50% of maximum. The EC50 in the above example is 30.2 pM (0.72 ng/mL).
(B) 3 μg of Human Recombinant BMP-4, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant BMP-4, ACF has a predicted molecular mass of 24 kDa (dimer).
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant BMP-4, ACF Catalog #
100-2071 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant BMP-4, ACF Catalog #
100-2071 Lot #
All Language
English 应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
Research Area
Workflow Stages
Workflow Stages for Mouse Pluripotent Stem Cell Research
Workflow Stages for Human Pluripotent Stem Cell Research
Workflow Stages for hPSC-Derived Endoderm Cell Research
Workflow Stages for hPSC-Derived Mesoderm Cell Research
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更多信息
| 种属 | Human |
|---|---|
| 配方类别 | Animal Component-Free |
| Alternative Names | BMP-2B, BMP2B1, MCOPS6, OFC11, ZYME |
| 纯度 | ≥ 98% by SDS-PAGE |
质量保证:
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
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