EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #100-2075_C
生长分化因子15，不含动物成分
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总览
生长分化因子-15 (GDF-15)，又称巨噬细胞抑制因子-1 (MIC-1)，是转化生长因子β (TGF-β)超家族的成员。在人体细胞组织中，生理性的GDF-15表达水平较低或不存在，但GDF-15水平升高与细胞应激、炎症、代谢疾病、癌症和其他疾病有关(Emmerson等；Wischhusen等)。GDF-15通过GFRAL （GDNF Family Receptor Alpha Like）及其共受体RET进行信号转导，导致RET的磷酸化，并激活ERK和AKT信号通路（Emmerson 等）。人重组GDF-15已用于小鼠研究（Kim等）。该产品经检测TGF-β活性为阴性，TGF-β是商业来源GDF-15的常见污染物（Olsen等）。本产品不含动物成分（ACF）。
亚型
细胞因子
别名
巨噬细胞抑制性细胞因子 1 (MIC-1)；NSAID 激活基因 1 蛋白 (NAG-1)；NSAID 调控基因 1 蛋白 (NRG-1)
种属
人
研究领域
神经科学，干细胞生物学
制剂类别
Animal Component-Free
纯度
SDS-PAGE 检测：≥ 98%
实验数据
Figure 1. Biological Activity and Molecular Mass of Human Recombinant GDF-15, ACF
(A) Human Recombinant GDF-15, ACF was tested by its ability to activate SMAD2/3 in HEK293T cells using a luciferase reporter assay. Firefly luciferase activity is normalized to the control Renilla luciferase activity. Increasing concentration of Human Recombinant GDF-15 did not result in increasing SMAD2/3 activity, indicating it is free of contamination with TGF-β or related growth factors.
(B) 7 μg of Human Recombinant GDF-15, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant GDF-15, ACF has a predicted molecular mass of 25 kDa (dimer).
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant GDF-15, ACF Catalog #
100-2076 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant GDF-15, ACF Catalog #
100-2076 Lot #
All Language
English Request Pricing
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更多信息
| 种属 | Human |
|---|---|
| 配方类别 | Animal Component-Free |
| Alternative Names | Macrophage inhibitory cytokine 1 (MIC-1), NSAID-activated gene 1 protein (NAG-1), NSAID-regulated gene 1 protein (NRG-1) |
| 纯度 | ≥ 98% by SDS-PAGE |
质量保证:
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
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