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人重组Heregulin - beta 1，ACF

Heregulin-beta 1，不含动物成分
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产品号 #100-2062_C

Heregulin-beta 1，不含动物成分

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总览
实验数据
产品说明书及文档
应用领域

总览

Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch et al.). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei & Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete et al.). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson et al.). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang et al.). This product is animal component-free (ACF).

亚型
细胞因子
 
别名
乙酰胆碱受体诱导活性；ARIA；乳腺癌细胞分化因子 p45；胶质生长因子；Heregulin 神经分化因子；HRG；HRG1；HRG1-beta 1；神经调节素-1；NRG1；NRG1-beta 1；感觉和运动神经元来源因子
 
细胞类型
癌细胞及细胞系，神经细胞，PSC衍生，神经干/祖细胞，神经元
 
种属
人，其它细胞系
 
研究领域
癌症，神经科学，干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
SDS-PAGE 检测：≥ 98%
 

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Data Figures

Biological Activity and Molecular Mass of Human Recombinant Heregulin-beta 1, ACF

Figure 1. Biological Activity and Molecular Mass of Human Recombinant Heregulin-beta 1, ACF

(A) The biological activity of Human Recombinant Heregulin-beta 1, ACF was tested by its ability to induce MAP/ERK signaling in transfected MCF-7 cells using a luciferase reporter assay. Firefly luciferase activity is normalized to the control Renilla luciferase activity. The EC50 is defined as the effective concentration of the growth factor at which Heregulin-beta 1 response is at 50% of maximum. The EC50 in the above example is 37.9 pM (0.28 ng/mL).

(B) 3 μg of Human Recombinant Heregulin-beta 1, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Heregulin-beta 1, ACF has a predicted molecular mass of 7.5 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant Heregulin-beta 1, ACF
Catalog #
100-2062
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant Heregulin-beta 1, ACF
Catalog #
100-2062
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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种属 Human, Other
配方类别 Animal Component-Free
Alternative Names Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin Neu differentiation factor, HRG, HRG1, HRG1-beta 1, Neuregulin-1, NRG1, NRG1-beta 1, Sensory and motor neuron-derived factor
纯度 ≥ 98% by SDS-PAGE
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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