产品号 #100-2062_C
Heregulin-beta 1,不含动物成分
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Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch et al.). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei & Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete et al.). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson et al.). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang et al.). This product is animal component-free (ACF).
亚型
细胞因子
别名
乙酰胆碱受体诱导活性;ARIA;乳腺癌细胞分化因子 p45;胶质生长因子;Heregulin 神经分化因子;HRG;HRG1;HRG1-beta 1;神经调节素-1;NRG1;NRG1-beta 1;感觉和运动神经元来源因子
细胞类型
癌细胞及细胞系,神经细胞,PSC衍生,神经干/祖细胞,神经元
种属
人,其它细胞系
研究领域
癌症,神经科学,干细胞生物学
制剂类别
Animal Component-Free
纯度
SDS-PAGE 检测:≥ 98%
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种属 | Human, Other |
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配方类别 | Animal Component-Free |
Alternative Names | Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin Neu differentiation factor, HRG, HRG1, HRG1-beta 1, Neuregulin-1, NRG1, NRG1-beta 1, Sensory and motor neuron-derived factor |
纯度 | ≥ 98% by SDS-PAGE |