产品号 #78019_C
肝细胞生长因子
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肝细胞生长因子/散射因子 (HGF/SF) 是一种多效性生长因子,可促进增殖、运动、存活和分化。HGF 结合并促进受体酪氨酸激酶 c-MET 的二聚化和活化,并刺激 PI3K/AKT、FAK、JNK 和 ERK1/2 信号传导 (Organ & Tsao)。HGF 在胚胎发生过程中刺激细胞迁移,诱导细胞运动和上皮细胞散射,并调节上皮-间质转化。它是运动神经元的趋化因子,调节感觉神经元、交感神经元、副交感神经元和皮质神经元的发育,以及少突胶质细胞的增殖和神经胶质细胞的发育。此外,HGF 还具有细胞保护作用,并调节肝脏的生长和再生(Nakamura et al.)。
亚型
细胞因子,生长因子
细胞类型
气道细胞,肝细胞,肠道细胞,乳腺细胞,神经元,多能干细胞,前列腺细胞
种属
人
研究领域
上皮细胞研究,神经科学,干细胞生物学
纯度
≥ 95 %
(A) The biological activity of Human Recombinant HGF was tested by its ability to promote the proliferation of 4MBr5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 7.2 ng/mL.
(B) 5 μg of Human Recombinant HGF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant HGF has a predicted molecular mass of 88 - 90 kDa (single chain), 59 - 61 kDa (alpha chain), or 30 - 34 kDa (beta chain).
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种属 | Human |
---|---|
纯度 | ≥ 95% |
成纤维细胞生长因子8B
Fms样酪氨酸激酶3/胎肝激酶2
粒细胞集落刺激因子
粒细胞-巨噬细胞集落刺激因子
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