EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #100-2060_C
胰岛素样生长因子1长精氨酸3，无动物成分
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总览
IGF-1长精氨酸3 （LR3）可结合胰岛素样生长因子1 （IGF-1）受体，是PI3K/AKT通路和ERK1/2信号通路的有效激活剂。IGF-1是一种多肽，属于胰岛素样生长因子家族，其分子结构与胰岛素原相似，是胰岛素样生长因子1的一种合成类似物 (IGF-I; Francis et al)。IGF-1 LR3对IGF结合蛋白（IGFBPs）的亲和力降低了100倍以上，从而降低了细胞培养中IGF的可用性（Voorhamme & Yandell）。IGF-1在胚胎发育过程中必不可少，主要在肝脏对肝细胞生长激素的刺激下产生。在缺乏胰岛素的情况下，IGF-1是人维持多能干细胞的关键因子（Wang et al.）。IGF-1与IL-3联合使用时，可促进髓系细胞的分化和增殖，还可通过促进淋巴器官中T细胞和B细胞的增殖和分化来调节淋巴细胞的生成（Heemskerk et al.）。本产品为无动物成分（ACF）级别。
亚型
细胞因子
别名
IBP1；IGF-IA；IGF-IB；IGF1A；胰岛素样生长因子 1；长型 R3 IGF-I；机械生长因子；MGF；生长因子 C
细胞类型
神经细胞，PSC衍生，神经干/祖细胞，前列腺细胞
种属
人，其它细胞系
研究领域
上皮细胞研究，神经科学，干细胞生物学
制剂类别
Animal Component-Free
纯度
SDS-PAGE 检测：≥ 98%
实验数据
Figure 1. Biological Activity and Molecular Mass of Human Recombinant IGF-I LR3, ACF
(A) The biological activity of Human Recombinant IGF-I LR3, ACF was tested by its ability to induce MAP/ERK signaling in transfected MCF-7 cells using a luciferase reporter assay. Firefly luciferase activity is normalized to the control Renilla luciferase activity. The EC50 is defined as the effective concentration of the growth factor at which IGF-I LR3 response is at 50% of maximum. The EC50 in the above example is 1.3 nM (11.7 ng/mL).
(B) 3 μg of Human Recombinant IGF-I LR3, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IGF-I LR3, ACF has a predicted molecular mass of 9 kDa.
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant IGF-I LR3, ACF Catalog #
100-2060 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IGF-I LR3, ACF Catalog #
100-2060 Lot #
All Language
English 应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
Research Area
Workflow Stages
Workflow Stages for Myeloid Cell Research
Workflow Stages for hPSC-Derived Endoderm Cell Research
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for Human Pluripotent Stem Cell Research
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更多信息
| 种属 | Human, Other |
|---|---|
| 配方类别 | Animal Component-Free |
| Alternative Names | IBP1, IGF-IA, IGF-IB, IGF1A, Insulin-like growth factor 1, Long R3 IGF-I, Mechano growth factor, MGF, Somatomedin C |
| 纯度 | ≥ 98% by SDS-PAGE |
质量保证:
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
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