EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #100-2064_C
R-spondin-3，不含动物成分
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总览
R-Spondin-3是血小板反应蛋白1型重复序列（TSR-1）超家族的成员，参与调控经典的Wnt/β-catenin信号通路（de Lau等）。R-spondin蛋白的特征是在氨基端具有两个furin类似的重复序列，而血小板反应蛋白结构域位于羧基端附近（de Lau等）。R-spondin-3的表达与卵巢癌（Gu等）、前列腺癌（Mesci等）以及糖尿病肠上皮细胞分化（Shan等）有关。在转基因小鼠模型中，R-Spondin-3的表达可诱导Lgr5+干细胞、Paneth细胞和Lgr4+细胞的扩增，从而促进肠道干细胞区的扩展（Hilkens等）。本产品不含动物成分（ACF）。
亚型
细胞因子
别名
Cristin 1，hRspo3，PWTSR，R-Spondin 3，脊髓板特异性脊蛋白-3，RSPO3，R-Spondin 3，含血小板反应素1型结构域蛋白2，THSD2
细胞类型
上皮细胞
种属
人
研究领域
类器官，干细胞生物学
制剂类别
Animal Component-Free
纯度
SDS-PAGE 检测：≥ 98%
实验数据
Figure 1. Biological Activity and Molecular Mass of Human Recombinant R-spondin-3, ACF
(A) The biological activity of Human Recombinant R-Spondin-3, ACF was tested by its ability to induce Wnt-ß catenin signaling in HEK239T cells using a luciferase reporter assay. Firefly luciferase activity was normalized to control Renilla luciferase activity. The EC50 is defined as the effective concentration of the growth factor at which Wnt-ß catenin response is at 50% of maximum. The EC50 in the above example is 0.3 nM (5 ng/mL).
(B) 7 μg of Human Recombinant R-spondin-3, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant R-spondin-3, ACF has a predicted molecular mass of 17 kDa.
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant R-spondin-3, ACF Catalog #
100-2065 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant R-spondin-3, ACF Catalog #
100-2065 Lot #
All Language
English Request Pricing
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更多信息
| 种属 | Human |
|---|---|
| 配方类别 | Animal Component-Free |
| Alternative Names | Cristin 1, hRspo3, PWTSR, R-Spondin 3, Roof plate-specific spondin-3, RSPO3, RSpondin 3, Thrombospondin type-1 domain-containing protein 2, THSD2 |
| 纯度 | ≥ 98% by SDS-PAGE |
质量保证:
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
产品仅供研究使用，不用于针对人或动物的诊断或治疗。
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