In this webinar, Dr. Christopher Y. Park, NYU School of Medicine discusses the conceptual and experimental principles of leukemic stem cell isolation. He gives an overview on the use of human primary cells for in vitro assays and the generation of xenograft models of myeloid malignancies, and provides novel insights derived from the study of purified disease stem cells in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).