In this webinar, Riya Sharma, Senior Scientist at STEMCELL Technologies, introduces new tools and workflows designed to support advanced organoid research in intestinal and hepatic biology. She presents IntestiCult™ Plus Organoid Growth Medium, a next-generation solution that enables modular, serum-free expansion and differentiation of human intestinal organoids. With enhanced regional and cell-type diversity confirmed by single-cell RNA sequencing, organoids grown in IntestiCult™ Plus more faithfully replicate the architecture and function of the intestinal epithelium. Riya demonstrates how these organoids exhibit mature morphologies, functional transporter activity, and responsiveness to CFTR modulation, drug toxicity, and drug metabolism assays.

The webinar also features STEMdiff™ Hepatic Organoid Media, optimized for the derivation and maturation of hepatic organoids from hPSC-derived hepatocyte-like cells. These hepatic organoids display hallmark protein expression and metabolic activity, and are highly responsive in assays modeling drug toxicity, CYP3A4 modulation, and cholestasis.

Together with the new Organoid Culture Plates that improve uniformity, imaging, and automation compatibility, these tools form a comprehensive platform supporting high-throughput and physiologically relevant organoid research for drug discovery, disease modeling, and toxicology testing.

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