EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #72582_C
WNT通路抑制剂
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总览
KY02111通过抑制经典WNT信号通路，促进多能干细胞(PSC)向心肌细胞分化，其方式与其他WNT抑制剂不同（Minami et al.）。
分化
·与BIO、CHIR99021和XAV939联合使用，可促进人和小鼠PSC向心肌细胞分化（Minami et al.）。
细胞类型
心肌细胞，PSC衍生，多能干细胞
种属
人，小鼠，非人灵长类，其它细胞系，大鼠
应用
分化
研究领域
干细胞生物学
CAS 编号
1118807-13-8
化学式
C₁₈H₁₇ClN₂O₃S
纯度
≥ 95 %
通路
WNT
产品说明书及文档
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应用领域
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相关材料与文献
技术资料 (2)
文献 (1)
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell reports 2012 NOV
Abstract
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem cells, are potentially useful in regenerative therapies for heart disease. For medical applications, clinical-grade cardiac cells must be produced from hPSCs in a defined, cost-effective manner. Cell-based screening led to the discovery of KY02111, a small molecule that promotes differentiation of hPSCs to cardiomyocytes. Although the direct target of KY02111 remains unknown, results of the present study suggest that KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs but in a manner that is distinct from that of previously studied WNT inhibitors. Combined use of KY02111 and WNT signaling modulators produced robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin. The methodology has potential as a means for the practical production of human cardiomyocytes for regeneration therapies.
更多信息
| 种属 | Human, Mouse, Non-Human Primate, Other, Rat |
|---|---|
| Cas Number | 1118807-13-8 |
| Chemical Formula | C₁₈H₁₇ClN₂O₃S |
| 纯度 | ≥ 95% |
| Pathway | WNT |
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