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Pyrintegrin

整合素和酪氨酸激酶激活剂;激活整合素、FGFR、IGFR和HER2

产品号 #(选择产品)

产品号 #72842_C

整合素和酪氨酸激酶激活剂;激活整合素、FGFR、IGFR和HER2

总览

Pyrintegrin是一种2,4-二取代嘧啶类化合物,可诱导β1整合素和多种生长因子受体的激活,包括FGFR1、IGFR1、EGFR1和HER2 ((Xu et al.)。

维持和自我更新
·在胰蛋白酶消化形成的单细胞状态下,增强人胚胎干细胞(ES)依赖整合素的黏附和存活能力(Xu et al.)。

细胞类型
多能干细胞
 
种属
人,小鼠,非人灵长类,其它细胞系,大鼠
 
应用
培养
 
研究领域
干细胞生物学
 
CAS 编号
1228445-38-2
 
化学式
C₂₃H₂₅N₅O₃S
 
纯度
≥ 95 %
 
通路
整合素,酪氨酸激酶
 
靶点
FGFR,HER2,IGFR,整合素
 

产品说明书及文档

请在《产品说明书》中查找相关支持信息和使用说明,或浏览下方更多实验方案。

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
Pyrintegrin
Catalog #
72842, 72844
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Pyrintegrin
Catalog #
72842, 72844
Lot #
All
Language
English

应用领域

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相关材料与文献

技术资料 (3)

文献 (1)

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Xu Y et al. Proceedings of the National Academy of Sciences of the United States of America 2010 MAY

Abstract

Using a high-throughput chemical screen, we identified two small molecules that enhance the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of action, we discovered an essential role of E-cadherin signaling for ESC survival. Specifically, we showed that the primary cause of hESC death following enzymatic dissociation comes from an irreparable disruption of E-cadherin signaling, which then leads to a fatal perturbation of integrin signaling. Furthermore, we found that stability of E-cadherin and the resulting survival of ESCs were controlled by specific growth factor signaling. Finally, we generated mESC-like hESCs by culturing them in mESC conditions. And these converted hESCs rely more on E-cadherin signaling and significantly less on integrin signaling. Our data suggest that differential usage of cell adhesion systems by ESCs to maintain self-renewal may explain their profound differences in terms of morphology, growth factor requirement, and sensitivity to enzymatic cell dissociation.

更多信息

更多信息
种属 Human, Mouse, Non-Human Primate, Other, Rat
Cas Number 1228445-38-2
Chemical Formula C₂₃H₂₅N₅O₃S
纯度 ≥ 95%
Target FGFR, HER2, IGFR, Integrin
Pathway Integrin, Tyrosine Kinase
质量保证:

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