EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #72842_C
整合素和酪氨酸激酶激活剂；激活整合素、FGFR、IGFR和HER2
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总览
Pyrintegrin是一种2,4-二取代嘧啶类化合物，可诱导β1整合素和多种生长因子受体的激活，包括FGFR1、IGFR1、EGFR1和HER2 （(Xu et al.）。
维持和自我更新
·在胰蛋白酶消化形成的单细胞状态下，增强人胚胎干细胞（ES）依赖整合素的黏附和存活能力（Xu et al.）。
细胞类型
多能干细胞
种属
人，小鼠，非人灵长类，其它细胞系，大鼠
应用
培养
研究领域
干细胞生物学
CAS 编号
1228445-38-2
化学式
C₂₃H₂₅N₅O₃S
纯度
≥ 95 %
通路
整合素，酪氨酸激酶
靶点
FGFR，HER2，IGFR，整合素
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
相关材料与文献
技术资料 (3)
文献 (1)
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proceedings of the National Academy of Sciences of the United States of America 2010 MAY
Abstract
Using a high-throughput chemical screen, we identified two small molecules that enhance the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of action, we discovered an essential role of E-cadherin signaling for ESC survival. Specifically, we showed that the primary cause of hESC death following enzymatic dissociation comes from an irreparable disruption of E-cadherin signaling, which then leads to a fatal perturbation of integrin signaling. Furthermore, we found that stability of E-cadherin and the resulting survival of ESCs were controlled by specific growth factor signaling. Finally, we generated mESC-like hESCs by culturing them in mESC conditions. And these converted hESCs rely more on E-cadherin signaling and significantly less on integrin signaling. Our data suggest that differential usage of cell adhesion systems by ESCs to maintain self-renewal may explain their profound differences in terms of morphology, growth factor requirement, and sensitivity to enzymatic cell dissociation.
更多信息
| 种属 | Human, Mouse, Non-Human Primate, Other, Rat |
|---|---|
| Cas Number | 1228445-38-2 |
| Chemical Formula | C₂₃H₂₅N₅O₃S |
| 纯度 | ≥ 95% |
| Target | FGFR, HER2, IGFR, Integrin |
| Pathway | Integrin, Tyrosine Kinase |
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