技术资料

实验方案
将小鼠实体瘤组织解离为单细胞悬液

研究方向：

免疫学，癌症研究
科学海报
CD2 Costimulation as a Method to Improve Mouse T Cell Activation by Soluble Antibody Complexes
产品手册
小鼠T细胞研究 - 细胞分选与培养

品牌：

EasySep
技术公告
Dendritic Cell/CD8+ T Cell Co-Culture to Assess Antigen-Specific T Cell Functionality

细胞类型：

CD8+ T细胞，T细胞，单核细胞，树突状细胞（DCs）
产品手册
Human T Cell Research Product Workflow

品牌：

ArciTect
14:21

视频
How to Isolate Immune Cells from Large-Volume Samples Using the Easy 250 EasySep™ Magnet
产品手册
Human B Cell Isolation Product Selection

品牌：

EasySep
产品手册
Human B Cell Research Product Workflow

品牌：

CryoStor
实验方案
How to Prepare a Single-Cell Suspension from Mouse Spleen Prior to Dendritic Cell Isolation

研究方向：

免疫学
Sato K et al. (JAN 2006) The Journal of experimental medicine 203 1 239--50

TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque.

Acute coronary syndromes (ACS) are precipitated by a rupture of the atherosclerotic plaque,often at the site of T cell and macrophage infiltration. Here,we show that plaque-infiltrating CD4 T cells effectively kill vascular smooth muscle cells (VSMC). VSMCs sensitive to T cell-mediated killing express the death receptor DR5 (TNF-related apoptosis-inducing ligand [TRAIL] receptor 2),and anti-TRAIL and anti-DR5 antibodies block T cell-mediated apoptosis. CD4 T cells that express TRAIL upon stimulation are expanded in patients with ACS and more effectively induce VSMC apoptosis. Adoptive transfer of plaque-derived CD4 T cells into immunodeficient mice that are engrafted with human atherosclerotic plaque results in apoptosis of VSMCs,which was prevented by coadministration of anti-TRAIL antibody. These data identify that the death pathway is triggered by TRAIL-producing CD4 T cells as a direct mechanism of VSMC apoptosis,a process which may lead to plaque destabilization. View Publication

产品号#：

15022

15062

产品名：

RosetteSep™人CD4+ T细胞富集抗体混合物

RosetteSep™人CD4+ T细胞富集抗体混合物
0:41

视频
Scale Up Your Cell Isolation
实验方案
Optimizing Delivery Efficiency with Fluorescent Dextran Using the CellPore™ Transfection System

研究方向：

免疫学，疾病建模，药物发现和毒性检测