Scientific Resources

Q&A: Applications of Human Intestinal Organoid Cultures in Drug Discovery

Measuring Neuronal Activity in Human Pluripotent Stem Cell-Derived Cerebral Organoids on 3D High-Density Multi-Electrode Arrays

Next-Generation Tools to Advance Your Human T Cell Research

How to Perform Albumin Detection Assays in Human Hepatic Organoids

Detection of CYP3A4 Activity in Human Hepatic Organoids by LC-MS

Exploring the Vitality of Lineage-Specific Chimerism Analysis After HSCT

Robust Scale-Up of hPSC-Derived Cardiomyocytes in 2D Monolayer Culture

How to Differentiate hiPSCs into Colonic Organoids Using STEMdiff™

Applications of Human Intestinal Organoid Cultures in Drug Discovery Human intestinal organoids provide a scalable and highly predictive model system for studying the effects of novel therapeutics in vitro. Intestinal organoids contain the relevant cell types that constitute the intestinal epithelium and, as such, can be maintained in various states of proliferation or differentiation. These physiologically relevant models reveal the toxicity of compounds that can not be seen in Caco-2 cells, which are frequently used to model the intestine during drug development programs.

In this webinar, Danny Leung and Dr. Victoria Conlin from STEMCELL Technologies describe, in detail, what intestinal organoids are, how they mimic the immunocytochemistry and morphology of the human gut epithelium, and how to use organoids for drug screening. They also discuss the intestinal organoid assays offered by Contract Assay Services (CAS) at STEMCELL Technologies.

Dr. Marta Costa

Reporting Practices for Publishing Results with hPSCs Learn how to plan and conduct your human pluripotent stem cell (hPSC)-based research following the ISSCR’s Standards for Human Stem Cell Use in Research

Efficient Generation of Functionally Relevant hPSC-Derived Hepatocytes and Liver Organoids for Hepatotoxicity and Liver Biology Modeling