Cori Fain
Cori Gain discusses her work in the Johnson lab focused on understanding immune-mediated blood-brain barrier disruption in cerebral malaria
Studying Cystic Fibrosis Using Primary Human Nasal Epithelial Cells
Cystic Fibrosis (CF) is a genetic disease that affects multiple organs in the body. The primary defects are in the airway and related to epithelial dysfunction. Technological advances have enabled researchers to study CF using specialized in vitro cell culture models to recapitulate the pseudostratified airway epithelium. In this webinar, Dr. Theo Moraes elaborates on the advantages of using nasal epithelial cell cultures to perform such studies and their implications for precision medicine in CF. He also discusses the Program for Individualized Cystic Fibrosis Therapy (CFIT)—a collaboration between CF Canada, SickKids Foundation, and The Hospital for Sick Children—and how it utilizes the nasal culture methodology to develop a nationally accessible resource and to accelerate the development of individualized therapies for CF patients.
Dr. Theo Moraes is a clinician and researcher at The Hospital for Sick Children and the SickKids Research Institute in Toronto, Canada.
Susanne Heinzel
Dr. Susanne Heinzel describes her work studying the molecular and cellular mechanisms underlying the regulation of clonal expansion of lymphocytes
CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
Cerebral organoids have proven themselves to be physiologically relevant models to study neurodevelopmental disorders such as microcephaly. Dr. Madeline Lancaster has previously shown that cerebral organoids derived from a microcephalic patient have defects that mimic the debilitating in vivo condition.* In this virtual poster presentation, Leon Chew discusses his work gene editing cerebral organoids to model microcephaly. Chew will walk you through how he used CRISPR-Cas9 to generate a mutated hPSC cell line, characterized the stable clones for cell quality attributes, and differentiated the cells to cerebral organoids. The resulting cerebral organoids were smaller and had defects in neuronal development similar to data from Lancaster et al.*
Leon Chew is a Scientist at STEMCELL Technologies, overseeing the development of cerebral organoid products.
*Lancaster MA et al. (2013) Cerebral organoids model human brain development and microcephaly. Nature 501(1): 373–9.
EasySep™小鼠TIL（CD45）正选试剂盒
Cori Fain Cori Gain discusses her work in the Johnson lab focused on understanding immune-mediated blood-brain barrier disruption in cerebral malaria
Studying Cystic Fibrosis Using Primary Human Nasal Epithelial Cells Cystic Fibrosis (CF) is a genetic disease that affects multiple organs in the body. The primary defects are in the airway and related to epithelial dysfunction. Technological advances have enabled researchers to study CF using specialized in vitro cell culture models to recapitulate the pseudostratified airway epithelium. In this webinar, Dr. Theo Moraes elaborates on the advantages of using nasal epithelial cell cultures to perform such studies and their implications for precision medicine in CF. He also discusses the Program for Individualized Cystic Fibrosis Therapy (CFIT)—a collaboration between CF Canada, SickKids Foundation, and The Hospital for Sick Children—and how it utilizes the nasal culture methodology to develop a nationally accessible resource and to accelerate the development of individualized therapies for CF patients.
Ensuring Optimal pH of hPSC Culture Medium Technical tip from our dedicated team of Product and Scientific Support specialists
Susanne Heinzel Dr. Susanne Heinzel describes her work studying the molecular and cellular mechanisms underlying the regulation of clonal expansion of lymphocytes
CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly Cerebral organoids have proven themselves to be physiologically relevant models to study neurodevelopmental disorders such as microcephaly. Dr. Madeline Lancaster has previously shown that cerebral organoids derived from a microcephalic patient have defects that mimic the debilitating in vivo condition.* In this virtual poster presentation, Leon Chew discusses his work gene editing cerebral organoids to model microcephaly. Chew will walk you through how he used CRISPR-Cas9 to generate a mutated hPSC cell line, characterized the stable clones for cell quality attributes, and differentiated the cells to cerebral organoids. The resulting cerebral organoids were smaller and had defects in neuronal development similar to data from Lancaster et al.*
