Svetlana Kotliarova and Howard A. Fine Glioblastoma multiforme is the most aggressive and most common malignant primary brain tumor in humans. We have partnered with Cancer Cell to bring you this SnapShot poster by Svetlana Kotliarova and Howard A. Fine. This poster highlights key concepts and mechanisms in glioblastoma multiforme biology, including gliomagenesis, angiogenesis, proliferation, invasion and metabolism. Details of pharmacological agents acting on each signaling pathway are also provided.