Neural induction is the first step in the differentiation of human embryonic stem cells and induced pluripotent stem cells to neural progenitor cells (NPCs), which can then differentiate to the mature cell types of the central nervous system. Neural “rosette” structures represent a readily recognizable morphological signature of early neural induction in embryoid body-based neural induction methods. STEMdiff™ Neural Rosette Selection Reagent is an enzyme-free reagent for the selective detachment of neural rosette clusters, without the need for any manual selection.