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抗人CD16抗体，克隆号3G8

小鼠抗人、恒河猴、食蟹猴CD16单克隆IgG1抗体
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产品号 #60041_C

小鼠抗人、恒河猴、食蟹猴CD16单克隆IgG1抗体

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

3G8抗体与CD16 （FcγRIII或低亲和力IgG受体III）反应，CD16是一种属于Ig超家族的1型跨膜糖蛋白。CD16以两种不同的亚型：CD16a，一种分子量为50 - 65 kDa的形式表达在NK细胞、活化的单核细胞、巨噬细胞和胎盘滋养细胞上；CD16b，一种~48 kDa的糖基磷脂酰肌醇（GPI）锚定形式表达在中性粒细胞、嗜碱性粒细胞和嗜酸性粒细胞上，发现至少有两种多态性变体，称为NA1和NA2。CD16与单体、聚合或复合形式IgG的Fc区结合较弱，特别是IgG1和IgG3同型。IgG与CD16亚型结合可诱导信号通路，调节多种类型的反应，包括抗体依赖性细胞介导的细胞毒性（ADCC）、吞噬、细胞因子释放和增殖。在基于抗体的检测和细胞分离实验中，CD16/IgG相互作用可导致非特异性标记，3G8抗体可作为阻断抗体减少非特异性结合。

亚型
一抗
 
靶抗原
CD16
 
别名
CD16A，CD16B，Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; FCR-10，FcRIII，IGFR3，IMD20
 
活性物种
Baboon，Capuchin Monkey，Chimpanzee，Common Marmoset，Cotton-Topped Tamarin，Cynomolgus，人，Macaque，Rhesus，Sooty Mangabey，Squirrel Monkey
 
偶联
Alexa Fluor 488，APC，Biotin 或 生物素，FITC，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
粒细胞及其亚群，单核细胞
 
种属
人，非人灵长类
 
应用
细胞分选，CyTOF，删除，ELISAs，流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀，中和及阻断
 
研究领域
免疫
 
克隆
3G8
 
基因编号
2214
 
同种型
IgG1，kappa
 

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实验数据

Data for Unconjugated

Figure 1. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD16 Antibody, Clone 3G8, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Data for Alexa Fluor® 488-Conjugated

Figure 2. Data for Alexa Fluor® 488-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD16 Antibody, Clone 3G8, Alexa Fluor® 488 (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Alexa Fluor® 488 (Catalog #60070AD) (solid line histogram).

Data for APC-Conjugated

Figure 3. Data for APC-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD16 Antibody, Clone 3G8, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ) (solid line histogram).

Data for Biotin-Conjugated

Figure 4. Data for Biotin-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD16 Antibody, Clone 3G8, Biotin, followed by streptavidin (SAV) APC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Biotin (Catalog #60070BT), followed by SAV APC (solid line histogram).

Data for FITC-Conjugated

Figure 5. Data for FITC-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD16 Antibody, Clone 3G8, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI) (solid line histogram).

Data for PE-Conjugated

Figure 6. Data for PE-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD16 Antibody, Clone 3G8, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE) (solid line histogram).

产品说明书及文档

请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, Alexa Fluor® 488
Catalog #
60041AD.1, 60041AD
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, APC
Catalog #
60041AZ.1, 60041AZ
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8
Catalog #
60041.1, 60041
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, PE
Catalog #
60041PE.1, 60041PE
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, FITC
Catalog #
60041FI, 60041FI.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, Biotin
Catalog #
60041BT.1, 60041BT
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, Alexa Fluor® 488
Catalog #
60041AD.1, 60041AD
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, APC
Catalog #
60041AZ.1, 60041AZ
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8
Catalog #
60041.1, 60041
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, PE
Catalog #
60041PE.1, 60041PE
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, FITC
Catalog #
60041FI, 60041FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD16 Antibody, Clone 3G8, Biotin
Catalog #
60041BT.1, 60041BT
Lot #
All
Language
English

应用领域

本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。

Research Area
Workflow Stages

更多信息

更多信息
种属 Human, Non-Human Primate
克隆 3G8
Gene Id 2214
Alternative Names CD16A, CD16B, Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; FCR-10, FcRIII, IGFR3, IMD20
同种型/isotype IgG1, kappa
法律声明:

Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com.

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