抗人CD38抗体，克隆HIT2

小鼠单克隆IgG1抗体，抗人、黑猩猩、马CD38

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产品号 #60014_C

小鼠单克隆IgG1抗体，抗人、黑猩猩、马CD38

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总览

实验数据

产品说明书及文档

应用领域

总览

HIT2抗体识别CD38，CD38是一种~45 kDa的II型跨膜糖蛋白，在许多细胞类型特别是白细胞上表达。CD38是一种具有环化酶和水解酶活性的外切酶（ADP-核糖基水解酶），介导淋巴细胞的活化、粘附和代谢。CD31是该受体的一种已知配体。在人体中，CD38在大多数造血细胞上表达，其表达水平根据细胞的分化和激活状态而变化。CD38在活化的T细胞、B细胞和浆细胞上高表达，在一些组织包括脑、肾、肝、卵巢、胰腺、胎盘、睾丸和某些类型的癌组织中也有高水平的表达。

该抗体克隆已被验证可用于评估EasySep™试剂盒（包括EasySep™人CD138正选试剂盒II（产品号 #17877）和EasySep™人全血和骨髓CD138正选试剂盒II（产品号 #17887））分选的细胞纯度。

亚型
一抗

靶抗原
CD38

别名
ADP-核糖基环化酶，T10

活性物种
Chimpanzee，Horse，人

偶联
Alexa Fluor 488，APC，Biotin 或生物素，FITC，PE，未偶联的

宿主物种
小鼠

细胞类型
B 细胞，造血干/祖细胞，血浆

种属
人，非人灵长类，其它细胞系

应用
细胞分选，CyTOF，流式细胞术，免疫细胞化学，免疫荧光，免疫组化，Western印迹

研究领域
免疫，干细胞生物学

克隆
HIT2

基因编号
952

同种型
IgG1，kappa

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实验数据

Figure 1. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD38 Antibody, Clone HIT2, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or a mouse IgG1, kappa isotype control antibody followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Figure 2. Data for Alexa Fluor® 488-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD38 Antibody, Clone HIT2, Alexa Fluor® 488 (filled histogram) or a mouse IgG1, kappa Alexa Fluor® 488 isotype control antibody (solid line histogram).

Figure 3. Data for PE-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD38 Antibody, Clone HIT2, PE (filled histogram) or a mouse IgG1, kappa PE isotype control antibody (solid line histogram).

Figure 4. Data for APC-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD38 Antibody, Clone HIT2, APC (filled histogram) or a mouse IgG1, kappa isotype control antibody, APC (solid line histogram).

Figure 5. Data for Biotin-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD38 Antibody, Clone HIT2, Biotin followed by streptavidin (SAV) APC (filled histogram), or a biotinylated mouse IgG1, kappa isotype control antibody followed by SAV APC (solid line histogram).

Figure 6. Data for FITC-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD38 Antibody, Clone HIT2, FITC (filled histogram) or a mouse IgG1, kappa isotype control antibody, FITC (solid line histogram).