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抗人CD41抗体,克隆HIP8

小鼠单克隆IgG1抗体,抗人、恒河猴、食蟹猴CD41

产品号 #(选择产品)

产品号 #60114_C

小鼠单克隆IgG1抗体,抗人、恒河猴、食蟹猴CD41

总览

HIP8抗体识别人CD41的~125 kDa GPIIbα亚基,CD41是一种异二聚体整合素,主要在血小板、巨核细胞、单核细胞和急性巨核母细胞白血病细胞上表达。GPIIbα亚基通过单二硫键与较小的~25 kDa亚基(GPIIbβ)相连。CD41的三种异构体是由选择性剪接产生的,其中一种只在癌细胞中表达。CD41以钙依赖的方式与CD61(整合素b3)非共价结合,形成CD41/CD61(或GPIIb/IIIa)复合物,该复合物已被鉴定为多种配体(包括纤维蛋白原、纤连蛋白、玻连蛋白和凝血酶)的受体。与CD41/CD61复合物的结合涉及配体中的RGD三肽序列,而在整合素介导的应答中,配体占据和配体介导的受体聚集都具有重要功能。据报导,HIP8抗体通过数种化合物阻断血小板聚集并抑制血小板活化。

亚型
一抗
 
靶抗原
CD41
 
别名
GPIIb,整合素α2b,整合素αIIb,ITGA2B,血小板糖蛋白IIb
 
活性物种
Baboon,Capuchin Monkey,Chimpanzee,Cynomolgus,人,Pig,Rhesus
 
偶联
APC,FITC,PE,未偶联的
 
宿主物种
小鼠
 
细胞类型
巨核细胞,血小板
 
种属
人,非人灵长类,其它细胞系
 
应用
CyTOF,流式细胞术,功能学筛选,免疫荧光,免疫组化,中和及阻断
 
研究领域
免疫
 
克隆
HIP8
 
基因编号
3674
 
同种型
IgG1,kappa
 

实验数据

Data for unconjugated

Figure 1. Data for Unconjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Data for APC-Conjugated

Figure 2. Data for APC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ, solid line histogram).

Data for FITC-Conjugated

Figure 3. Data for FITC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI, solid line histogram).

Data for PE-Conjugated

Figure 4. Data for PE-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE, solid line histogram).

产品说明书及文档

请在《产品说明书》中查找相关支持信息和使用说明,或浏览下方更多实验方案。

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
60114PE, 60114PE.1
Lot #
All
Language
English
Catalog #
60114
Lot #
All
Language
English
Catalog #
60114FI, 60114FI.1
Lot #
All
Language
English
Catalog #
60114AZ, 60114AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60114PE, 60114PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60114
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60114FI, 60114FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60114AZ, 60114AZ.1
Lot #
All
Language
English

相关材料与文献

技术资料 (2)

更多信息

更多信息
种属 Human, Non-Human Primate, Other
克隆 HIP8
Gene Id 3674
Alternative Names GPIIb, Integrin alpha 2b, Integrin alpha llb, ITGA2B, Platelet glycoprotein IIb
同种型/isotype IgG1, kappa
法律声明:

Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com.

质量保证:

产品仅供研究使用,不用于针对人或动物的诊断或治疗。 欲获悉更多关于STEMCELL的质控信息,请访问 STEMCELL.CN/COMPLIANCE.
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