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抗人CD41抗体，克隆HIP8

小鼠单克隆IgG1抗体，抗人、恒河猴、食蟹猴CD41
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产品号 #60114_C

小鼠单克隆IgG1抗体，抗人、恒河猴、食蟹猴CD41

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总览
实验数据
产品说明书及文档
相关材料与文献
相关产品

总览

HIP8抗体识别人CD41的~125 kDa GPIIbα亚基，CD41是一种异二聚体整合素，主要在血小板、巨核细胞、单核细胞和急性巨核母细胞白血病细胞上表达。GPIIbα亚基通过单二硫键与较小的~25 kDa亚基（GPIIbβ）相连。CD41的三种异构体是由选择性剪接产生的，其中一种只在癌细胞中表达。CD41以钙依赖的方式与CD61（整合素b3）非共价结合，形成CD41/CD61（或GPIIb/IIIa）复合物，该复合物已被鉴定为多种配体（包括纤维蛋白原、纤连蛋白、玻连蛋白和凝血酶）的受体。与CD41/CD61复合物的结合涉及配体中的RGD三肽序列，而在整合素介导的应答中，配体占据和配体介导的受体聚集都具有重要功能。据报导，HIP8抗体通过数种化合物阻断血小板聚集并抑制血小板活化。

亚型
一抗
 
靶抗原
CD41
 
别名
GPIIb，整合素α2b，整合素αIIb，ITGA2B，血小板糖蛋白IIb
 
活性物种
Baboon，Capuchin Monkey，Chimpanzee，Cynomolgus，人，Pig，Rhesus
 
偶联
APC，FITC，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
巨核细胞，血小板
 
种属
人，非人灵长类，其它细胞系
 
应用
CyTOF，流式细胞术，功能学筛选，免疫荧光，免疫组化，中和及阻断
 
研究领域
免疫
 
克隆
HIP8
 
基因编号
3674
 
同种型
IgG1，kappa
 

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实验数据

Data for unconjugated

Figure 1. Data for Unconjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Data for APC-Conjugated

Figure 2. Data for APC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ, solid line histogram).

Data for FITC-Conjugated

Figure 3. Data for FITC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI, solid line histogram).

Data for PE-Conjugated

Figure 4. Data for PE-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE, solid line histogram).

产品说明书及文档

请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, PE
Catalog #
60114PE, 60114PE.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8
Catalog #
60114
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, FITC
Catalog #
60114FI, 60114FI.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, APC
Catalog #
60114AZ, 60114AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, PE
Catalog #
60114PE, 60114PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8
Catalog #
60114
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, FITC
Catalog #
60114FI, 60114FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, APC
Catalog #
60114AZ, 60114AZ.1
Lot #
All
Language
English

相关材料与文献

技术资料 (2)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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更多信息
种属 Human, Non-Human Primate, Other
克隆 HIP8
Gene Id 3674
Alternative Names GPIIb, Integrin alpha 2b, Integrin alpha llb, ITGA2B, Platelet glycoprotein IIb
同种型/isotype IgG1, kappa
法律声明:

Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com.

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