抗小鼠 CD138（Syndecan-1）抗体，克隆 281-2

抗小鼠 CD138（syndecan-1）的大鼠单克隆 IgG2a 抗体

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产品号 #60035_C

抗小鼠 CD138（syndecan-1）的大鼠单克隆 IgG2a 抗体

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总览

实验数据

产品说明书及文档

应用领域

总览

281-2抗体可与小鼠CD138（Syndecan-1）核心蛋白上的胞外表位发生反应。Syndecan-1是一种分子量约为60-100 kDa的1型跨膜糖蛋白，表达于前B细胞、未成熟B细胞以及正常和恶性浆细胞（但不表达于成熟的循环B细胞）的表面。CD138也表达于非造血细胞，例如胚胎间充质细胞、内皮细胞、上皮细胞和神经细胞。CD138被认为主要作为一种受体，通过将细胞外基质连接到细胞骨架来调节细胞增殖、细胞迁移和细胞基质结合。CD138上附着的硫酸肝素和硫酸软骨素部分可与多种蛋白质结合，包括胶原蛋白、纤连蛋白、肌腱蛋白、血小板反应蛋白和某些细胞因子。

亚型
一抗

靶抗原
CD138 (Syndecan-1)

别名
B-B4，SDC1，突触黏附素‑1

活性物种
小鼠

偶联
APC，Biotin 或生物素，PE，未偶联的

宿主物种
大鼠

细胞类型
B 细胞，血浆

种属
小鼠

应用
细胞分选，流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀，Western印迹

研究领域
癌症，免疫

克隆
281-2

基因编号
20969

同种型
IgG2a，kappa

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实验数据

Figure 1. Data for Unconjugated

Flow cytometry analysis of Sp2/0 mouse myeloma cells labeled with Anti-Mouse CD138 Antibody, Clone 281-2, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or Rat IgG2a, kappa Isotype Control Antibody, Clone RTK2758 (Catalog #60076), followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Figure 2. Data for APC-Conjugated

(A) Flow cytometry analysis of Sp2/0 mouse myeloma cells labeled with Anti-Mouse CD138 Antibody, Clone 281-2, APC (filled histogram) or Rat IgG2a, kappa Isotype Control Antibody, Clone RTK2758, APC (Catalog #60076AZ) (solid line histogram). (B) Flow cytometry analysis of naïve C57BL/6 mouse splenocytes labeled with Anti-Mouse CD138 Antibody, Clone 281-2, APC and Anti-Mouse CD45R Antibody, Clone RA3-6B2, FITC (Catalog #60019FI). (C) Flow cytometry analysis of naïve C57BL/6 mouse splenocytes labeled with Rat IgG2a, kappa Isotype Control Antibody, Clone RTK2758, APC and Anti-Mouse CD45R Antibody, Clone RA3-6B2, FITC.

Figure 3. Data for Biotin-Conjugated

(A) Flow cytometry analysis of Sp2/0 mouse myeloma cells labeled with Anti-Mouse CD138 Antibody, Clone 281-2, Biotin, followed by streptavidin (SAV) APC (filled histogram), or Rat IgG2a, kappa Isotype Control Antibody, Clone RTK2758, Biotin (Catalog #60076BT), followed by SAV APC (solid line histogram). (B) Flow cytometry analysis of naïve C57BL/6 mouse splenocytes labeled with Anti-Mouse CD138 Antibody, Clone 281-2, Biotin, followed by SAV APC and Anti-Mouse CD45R Antibody, Clone RA3-6B2, FITC (Catalog #60019FI). (C) Flow cytometry analysis of naïve C57BL/6 mouse splenocytes labeled with Rat IgG2a, kappa Isotype Control Antibody, Clone RTK2758, Biotin, followed by SAV APC and Anti-Mouse CD45R Antibody, Clone RA3-6B2, FITC.

Figure 4. Data for PE-Conjugated

(A) Flow cytometry analysis of Sp2/0 mouse myeloma cells labeled with Anti-Mouse CD138 Antibody, Clone 281-2, PE (filled histogram) or Rat IgG2a, kappa Isotype Control Antibody, Clone RTK2758, PE (Catalog #60076PE) (solid line histogram). (B) Flow cytometry analysis of naïve C57BL/6 mouse splenocytes labeled with Anti-Mouse CD138 Antibody, Clone 281-2, PE and Anti-Mouse CD45R Antibody, Clone RA3-6B2, APC (Catalog #60019AZ). (C) Flow cytometry analysis of naïve C57BL/6 mouse splenocytes labeled with Rat IgG2a, kappa Isotype Control Antibody, Clone RTK2758, PE and Anti-Mouse CD45R Antibody, Clone RA3-6B2, APC.