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人重组HGF(大肠杆菌表达），ACF

肝细胞生长因子，无动物成分
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产品号 #100-1727_C

肝细胞生长因子，无动物成分

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实验数据
产品说明书及文档
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总览

肝细胞生长因子/分散因子（HGF/SF）是一种多效性生长因子，可促进增殖、迁移、存活和分化。HGF结合并促进受体酪氨酸激酶c-MET的二聚化和激活，刺激PI3K/AKT、FAK、JNK和ERK1/2等信号通路（Organ & Tsao. Ther Adv Med Oncol, 2011)。HGF在胚胎发生过程中促进细胞迁移，诱导上皮细胞的运动和散射，调节上皮-间质转化。其为运动神经元的趋化因子，调节感觉、交感、副交感和皮质神经元的发育，以及促进少突胶质细胞的增殖和神经胶质细胞的发育。此外，HGF具有细胞保护作用，调节肝脏生长和再生（Nakamura et al. J Gastroenterol Hepatol, 2011）。

亚型
细胞因子
 
别名
DFNB39；F-TCF；成纤维细胞来源肿瘤细胞毒因子；肝造血素 A；HPTA；肺成纤维细胞来源的有丝分裂原；散布因子；SF
 
细胞类型
气道细胞，肝细胞，肠道细胞，乳腺细胞，神经元，多能干细胞，前列腺细胞
 
种属
人
 
研究领域
上皮细胞研究，神经科学，干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
≥98%
 

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实验数据

Figure 1. Biological Activity and Molecular Mass of Human Recombinant HGF (E. coli-expressed), ACF

(A) The biological activity of Human Recombinant HGF (E.coli-expressed), ACF was tested by its ability to induce MAP/ERK signaling in transfected HEK293T cells. Cells were treated with a serial dilution of HGF for 6 hours, and the activity was quantified by a luciferase reporter assay. The EC50 is defined as the effective concentration of the growth factor at which MAP/ERK activity is at 50% of maximum. The EC50 in the above example is ≤ 49.6 pM (0.99 ng/mL). (B) 7 μg of Human Recombinant HGF (E.coli-expressed), ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant HGF has a predicted molecular mass of 21 kDa in reducing conditions and 18 kDa in non-reducing conditions.

产品说明书及文档

请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant HGF (E. coli-expressed), ACF
Catalog #
100-1727, 100-1728
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant HGF (E. coli-expressed), ACF
Catalog #
100-1727
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant HGF (E. coli-expressed), ACF
Catalog #
100-1728
Lot #
All
Language
English

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更多信息
种属 Human
配方类别 Animal Component-Free
Alternative Names DFNB39, F-TCF, Fibroblast-derived tumor cytotoxic factor, Hepapoietin A, HPTA, Lung fibroblast-derived mitogen, Scatter factor, SF
纯度 ≥ 98%
质量保证:

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