产品号 #78214_C
核因子κB受体激活因子配体
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核因子κB受体激活因子配体(RANKL)是肿瘤坏死因子(TNF)超家族的成员(Anderson等人)。TNF超家族中的细胞因子参与多种长期细胞活动,如分化、增殖和细胞死亡(MacEwan)。RANKL是一种II型同型三聚体跨膜蛋白,以膜结合和分泌形式表达(Ikeda等人)。RANKL可与其受体—核因子κB受体活化因子(RANK)结合。结合后,RANKL可激活AKT信号通路(Moon 等人)。骨保护素(OPG)也可与RANKL结合,这种结合与RANKL- RANKL的结合相互竞争(Lacey等人)。RANKL参与破骨细胞的生成(Lacey等人;Yasuda等人)和T细胞的活化(Wong等人)。
亚型
细胞因子
别名
CD254,hRANKL2,ODF,OPGL,OPTB2,破骨细胞分化因子, 可溶性NF-κB受体活化配体,sOdf,肿瘤坏死因子相关活化诱导细胞因子,TNFSF11,肿瘤坏死因子超家族成员11,TNLG6B,肿瘤坏死因子超家族成员11,TRA
细胞类型
气道细胞,癌细胞及细胞系,树突状细胞(DCs),肠道细胞,乳腺细胞,成骨细胞,其它细胞系,胰腺细胞,前列腺细胞,T 细胞
种属
人
研究领域
癌症,干细胞生物学
纯度
≥ 95 %
(A) The biological activity of Human Recombinant RANKL was tested by its ability to induce production of embryonic alkaline phosphatase in RAW-Blue™ macrophage reporter cells. Alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 38.8 ng/mL. (B) Human Recombinant RANKL was resolved with SDS-PAGE under reducing (+) conditions and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant RANKL has a predicted molecular mass of 19.7 kDa.
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种属 | Human |
---|---|
Alternative Names | CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoclast differentiation factor, soluble Receptor activator of NF-κB ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TNF superfamily member 11, TNLG6B, Tumor necrosis factor superfamily member 11, TRA |
纯度 | ≥ 95% |
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