重组人TNF - β

肿瘤坏死因子β

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产品号 #78125_C

肿瘤坏死因子β

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总览

实验数据

产品说明书及文档

应用领域

总览

肿瘤坏死因子-β (TNF-β)，也称为淋巴毒素- α，是TNF家族的一员。它是一种促炎细胞因子，通过与TNF受体1和2结合，可激活NF-kB、MAPK和PI3K/AKT通路。它主要由T细胞产生，尽管其他细胞可以表达较低水平的TNF-β (Chu)。TNF-β参与自身免疫性疾病、淋巴结的发育和介导炎症性脱髓鞘过程(Seleznik等人；McCarthy等人)。

亚型
细胞因子

细胞类型
T 细胞

种属
人

研究领域
免疫

纯度
≥ 95 %

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实验数据

(A) The biological activity of Human Recombinant TNF-beta was tested by its ability to inhibit growth of mouse L929 cells growing in the presence of actinomycin D. Cell growth was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.004 ng/mL. (B) 2 μg of Human Recombinant TNF-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.