产品号 #78049_C
白介素5
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白介素5 (IL-5)是造血细胞因子短链4-α-螺旋束亚群中的一员。它与特定的α受体结合,进而募集共同的β受体,通过JAK/STAT和MAPK通路启动信号传导。IL-5由Th2细胞、嗜酸性粒细胞、活化肥大细胞和ILC2细胞产生。IL-5影响嗜酸性粒细胞的分化、活化和存活,在变应性炎症、哮喘和寄生虫免疫中发挥重要作用。IL-5刺激嗜酸性粒细胞可导致其活化、CD11b表达上调和细胞凋亡抑制(Shearer)。
亚型
细胞因子
细胞类型
B 细胞,粒细胞及其亚群,造血干/祖细胞
种属
小鼠
研究领域
免疫,干细胞生物学
纯度
≥ 95 %
(A) The biological activity of Mouse Recombinant IL-5 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 70 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.15 - 0.22 ng/mL.
(B) 1 μg of Mouse Recombinant IL-5 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-5 has a predicted molecular mass of 26.3 kDa.
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种属 | Mouse |
---|---|
纯度 | ≥ 95% |
粒细胞-巨噬细胞集落刺激因子
白介素3
白介素4
白介素5
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