产品号 #100-0943_C
核因子kappa-Β配体受体激活剂(RANKL),无动物源成分
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核因子kappa-Β配体受体激活剂(RANKL)是肿瘤坏死因子(TNF)超家族的成员之一(Anderson等)。TNF超家族中的细胞因子广泛参与多种长期细胞活动,如细胞分化、增殖和细胞死亡(MacEwan)。RANKL是一种II型同型三聚体跨膜蛋白,能够在膜结合和分泌形式中表达(Ikeda等)。RANKL与核因子kappa-Β受体激活因子(RANK)结合。一旦与其受体结合后,可激活AKT信号通路(Moon等)。骨保护素(OPG)也可与RANKL结合,这种结合与RANKL-RANK结合相互竞争(Lacey等)。RANKL参与破骨细胞生成(Lacey等;Yasuda等)和T细胞活化(Wong等)。本产品不含动物源成分。
别名
CD254;hRANKL2;ODF;OPGL;OPTB2;成骨细胞分化因子;可溶性NF-κB配体受体激活因子;sOdf;肿瘤坏死因子相关激活诱导细胞因子;TNF相关的激活诱导细胞因子;TNFSF11;肿瘤坏死因子超家族成员11;TNLG6B;肿瘤坏死因子超家族成员11;TRAN
细胞类型
T 细胞
种属
小鼠
研究领域
癌症,免疫
制剂类别
Animal Component-Free
纯度
≥ 95 %
Figure 1.
(A) The activity of Mouse Recombinant RANKL, ACF was tested by its ability to activate RAW-BlueTM cells. The EC50 is defined as the effective concentration of the growth factor at which binding is at 50% of maximum. The EC50 in the above example is 11.3 ng/mL. (B) Mouse Recombinant RANKL, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant RANKL, ACF has a predicted molecular mass of 19.5 kDa (monomer).
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种属 | Mouse |
---|---|
配方类别 | Animal Component-Free |
Alternative Names | CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoclast differentiation factor, soluble Receptor activator of NF-κB ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TNF superfamily member 11, TNLG6B, Tumor necrosis factor superfamily member 11, TRAN |
纯度 | ≥ 95% |
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