产品号 #78072_C
血小板生成素
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血小板生成素 (TPO) 是体内外巨核细胞生成和血小板生成的关键调节因子。TPO 刺激巨核细胞增殖和成熟,并在调节体内循环血小板水平方面发挥重要作用。TPO 还促进造血干细胞和原始多谱系祖细胞的存活、自我更新和扩增。它通常与其他细胞因子(例如干细胞因子 (SCF) 和 Flt3/Flk-2 配体)一起使用,以促进培养的原始造血细胞扩增 (Hitchcock & Kaushansky)。TPO 受体 c-Mpl 在巨核细胞生成的所有阶段均有表达,从造血干细胞和祖细胞到成熟的血小板。
亚型
细胞因子
细胞类型
造血干/祖细胞,中胚层,PSC衍生,多能干细胞
种属
小鼠
研究领域
干细胞生物学
纯度
≥ 95 %
(A) The biological activity of Mouse Recombinant TPO was tested by its ability to promote the proliferation of MO7e cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.92 ng/mL. (B) 5 μg of Mouse Recombinant TPO was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant TPO has a predicted molecular mass of 35 kDa but as a result of glycosylation has an apparent molecular mass of approximately 75 kDa.
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种属 | Mouse |
---|---|
纯度 | ≥ 95% |
Fms样酪氨酸激酶3/胎肝激酶2
白介素6
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