抗大鼠CD90抗体，克隆OX-7

小鼠单克隆IgG1抗体，抗小鼠、大鼠、豚鼠CD90/CD90.1

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产品号 #60024_C

小鼠单克隆IgG1抗体，抗小鼠、大鼠、豚鼠CD90/CD90.1

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总览

实验数据

产品说明书及文档

应用领域

总览

OX-7抗体识别大鼠CD90 （Thy-1）和小鼠CD90.1 （Thy-1.1），后者是小鼠品系AKR/J、PL和FVB/N表达的CD90等位形式。OX-7抗体不能识别CD90.2（在许多小鼠品系中表达，包括CBA和BALB/c）。CD90是一种GPI连接的膜糖蛋白，是免疫球蛋白超家族的成员。25 kDa的核心蛋白在三个位点被N-糖基化，产生分子量范围在25 - 37 kDa的分子。在大鼠中，CD90在多种细胞类型中表达，包括造血干细胞、未成熟B细胞、胸腺细胞和神经元。在表达CD90.1的小鼠品系中，在骨髓的早期造血细胞、胸腺细胞和循环成熟T细胞中皆发现了CD90.1。OX-7抗体据报导可诱导白细胞活化、肾小球肾炎、肾小球系膜细胞凋亡和血管通透性。

该抗体克隆已被验证可用于评估EasySep™试剂盒（包括EasySep™小鼠T细胞分选试剂盒（产品号 #19851）从兼容的小鼠品系中分选的细胞纯度。

亚型
一抗

靶抗原
CD90/CD90.1

别名
Thy-1，Thy-1.1

活性物种
Guinea Pig，小鼠，兔，大鼠

偶联
Alexa Fluor 488，APC，Biotin 或生物素，FITC，PE，未偶联的

宿主物种
小鼠

细胞类型
T 细胞

种属
小鼠，其它细胞系，大鼠

应用
流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀，Western印迹

研究领域
免疫

克隆
OX-7

基因编号
21838/24832

同种型
IgG1，kappa

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实验数据

Figure 1. Data for Alexa Fluor® 488-Conjugated

(A) Flow cytometry analysis of Sprague-Dawley rat brain cells labeled with Anti-Rat CD90 Antibody, Clone OX-7, Alexa Fluor® 488 (filled histogram) or a mouse IgG1, kappa Alexa Fluor® 488 isotype control antibody (solid line histogram).
(B) Flow cytometry analysis of Sprague-Dawley rat thymocytes labeled with Anti-Rat CD90 Antibody, Clone OX-7, Alexa Fluor® 488 (filled histogram) or a mouse IgG1, kappa Alexa Fluor® 488 isotype control antibody (solid line histogram).

Figure 2. Data for PE-Conjugated

(A) Flow cytometry analysis of Sprague-Dawley rat brain cells labeled with Anti-Rat CD90 Antibody, Clone OX-7, PE (filled histogram) or a mouse IgG1, kappa PE isotype control antibody (solid line histogram).
(B) Flow cytometry analysis of Sprague-Dawley rat thymocytes labeled with Anti-Rat CD90 Antibody, Clone OX-7, PE (filled histogram) or a mouse IgG1, kappa PE isotype control antibody (solid line histogram).

Figure 3. Data for Unconjugated

(A) Flow cytometry analysis of Sprague-Dawley rat brain cells labeled with Anti-Rat CD90 Antibody, Clone OX-7, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram). (B) Flow cytometry analysis of Sprague-Dawley rat thymocytes labeled with Anti-Rat CD90 Antibody, Clone OX-7, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Figure 4. Data for APC-Conjugated

(A) Flow cytometry analysis of Sprague-Dawley rat brain cells labeled with Anti-Rat CD90 Antibody, Clone OX-7, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ) (solid line histogram). (B) Flow cytometry analysis of Sprague-Dawley rat thymocytes labeled with Anti-Rat CD90 Antibody, Clone OX-7, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (solid line histogram).

Figure 5. Data for Biotin-Conjugated

(A) Flow cytometry analysis of Sprague-Dawley rat brain cells labeled with Anti-Rat CD90 Antibody, Clone OX-7, Biotin, followed by streptavidin (SAV) APC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Biotin (Catalog #60070BT), followed by SAV APC (solid line histogram). (B) Flow cytometry analysis of Sprague-Dawley rat thymocytes labeled with Anti-Rat CD90 Antibody, Clone OX-7, Biotin, followed by SAV APC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Biotin, followed by SAV APC (solid line histogram).

Figure 6. Data for FITC-Conjugated

(A) Flow cytometry analysis of Sprague-Dawley rat brain cells labeled with Anti-Rat CD90 Antibody, Clone OX-7, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI) (solid line histogram). (B) Flow cytometry analysis of Sprague-Dawley rat thymocytes labeled with Anti-Rat CD90 Antibody, Clone OX-7, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (solid line histogram).