Highly Characterized Human iPSCs and NPCs for Downstream Differentiation Applications
Reproducible research with human induced pluripotent stem cells (iPSCs) depends on access to thoroughly characterized and quality-controlled cell lines. In this webinar, Drs. Andrew Gaffney and Erin Knock will describe the generation of a standardized induced pluripotent stem cell (iPSC) line. Developed with the upcoming ISSCR Standards Initiative characterization guidelines in mind, this highly characterized line is karyotypically stable, demonstrates trilineage differentiation potential, and expresses undifferentiated cell markers. Further, STEMCELL has developed a highly pure, ready-to-use neural progenitor cell product expressing PAX6 and SOX1 over multiple passages. Dr. Knock will show how these multipotent cells are suitable for customized downstream differentiation to various CNS cell types, such as forebrain neurons, midbrain neurons, and astrocytes. These progenitor cells are the ideal controls for standardizing downstream differentiation protocols, modeling diseases, and developing assays.
Madeline Lancaster on Brain Organoids: Modeling Human Brain Development in a Dish
In this webinar, Dr. Madeline Lancaster, who has done groundbreaking work in the development of cerebral organoid technology, discusses the latest developments in cerebral organoids and provides a comparison of different 3D model systems being used for neurological research.
Research in the Lancaster lab focuses on human brain development using cerebral organoids, a new in vitro model system for neurological development and disease research. The laboratory uses these ‘mini-brains’ to study the most fundamental differences between human and other mammalian species’ brain development - essentially, what makes us human. The lab is also studying cellular mechanisms of, and potential therapeutic avenues for, neurodevelopmental disorders such as autism and intellectual disability.
This webinar is just one of the educational resources on neural organoids that we’ve developed to help you navigate this exciting field. Visit the Neural Organoid Information Hub to learn more.
“Developing Regenerative Medicines” Featuring Dr. Stefan Irion
On this episode of the Stem Cell Podcast, Dr. Stefan Irion from BlueRock Therapeutics discusses the company’s Parkinson’s disease trial and the challenges of genetically manipulating stem cells.
“Neuronal Diversity” Featuring Dr. Paola Arlotta
On this episode of the Stem Cell Podcast, Dr. Paola Arlotta from Harvard University talks about brain organoids as models for human development, neuropsychiatric disorders, and neurodegenerative diseases.
Wardiya Saber
Dr. Wardiya Afshar Saber describes her work examining synaptic activity in Alzheimer’s disease using optogenetics and stem cell technology