Scientific Resources

Antiviral response mechanisms in a Jamaican Fruit Bat intestinal organoid model of SARS-CoV-2 infection.

PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression.

Generation and immunofluorescent validation of gene knockouts in adult human colonic organoids using multi-guide RNA CRISPR-Cas9.

Development and characterization of monoclonal antibodies directed against the nucleoprotein of heartland virus

3D bioprinted colorectal cancer models based on hyaluronic acid and signalling glycans.

In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice.

A novel human IgA monoclonal antibody protects against tuberculosis

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.

Implementing the Colony-Forming Unit (CFU) Assay As a Potency Assay for Hematopoietic Cell Therapy Products Assessing the functional potency of cells for use in cell therapy research presents unique challenges. For hematopoietic stem and progenitor cells (HSPCs) in particular, potency can be measured in vitro by assessing the ability of these cells to differentiate into progenitor cells using the colony-forming unit (CFU) assay. Validating the CFU assay as a potency assay requires demonstrating its specificity, accuracy, precision, linearity, and reproducibility. Once validated, the CFU assay can assess the quality and consistency of prospective hematopoietic cell therapy products (HCTPs) at multiple stages of the processing and manufacturing workflow.

Join Dr. Colin Hammond and learn about the regulatory guidance around the potency testing of HCTPs and how to validate the CFU assay as a potency assay that can be integrated into cell therapy manufacturing workflows.

Thinking Outside the Dome: Versatile Organotypic Cell Culture Methods

Comparative Study: Improving the Genetic Stability of Single-Cell-Passaged Human Pluripotent Stem Cell Cultures Using eTeSR™

Q&A: Applications of Human Intestinal Organoid Cultures in Drug Discovery