Modeling Host-Microbe Interactions Using Human Intestinal Organoids
A common challenge to studying host-microbe interactions is the lack of optimal in vitro culture systems to recapitulate in vivo infection. In this virtual paper presentation, Dr. Devanjali Dutta discusses her research using human intestinal and lung organoids to study Cryptosporidium infection. Cryptosporidium is a protozoan parasite, a leading cause of diarrhea, and a major cause of child mortality worldwide. Dr. Dutta describes how she—and her colleagues in the lab of Dr. Hans Clevers—infected intestinal and lung organoids derived from healthy human donors with Cryptosporidium. In their paper*, organoids are presented as a physiologically relevant in vitro model to study Cryptosporidium and other pathogenic infections.
Dr. Devanjali Dutta is a Postdoctoral researcher in the lab of Dr. Hans Clever at the Hubrecht Institute.
*Heo I, Dutta D et al. (2018) Nat Microbiol. 3(7):814–23.
SnapShot: Exercise Metabolism
Overview on the skeletal muscle gene expression modulation, energy sources, and inter-organ communications during exercise
Travis Jackson
Dr. Travis Jackson describes his research investigating cell signaling mechanisms contributing to neuronal or axonal injury
Wardiya Saber
Dr. Wardiya Afshar Saber describes her work examining synaptic activity in Alzheimer’s disease using optogenetics and stem cell technology
Organoid Expert Panel
What could organoids do for your research? In this in-depth panel discussion, STEMCELL's organoid experts answer questions submitted by you. Topics include evaluating organoids as tissue and disease models, variability in organoid cultures, and future outlooks in translational and clinical applications.
EasySep™小鼠TIL（CD45）正选试剂盒
Modeling Host-Microbe Interactions Using Human Intestinal Organoids A common challenge to studying host-microbe interactions is the lack of optimal in vitro culture systems to recapitulate in vivo infection. In this virtual paper presentation, Dr. Devanjali Dutta discusses her research using human intestinal and lung organoids to study Cryptosporidium infection. Cryptosporidium is a protozoan parasite, a leading cause of diarrhea, and a major cause of child mortality worldwide. Dr. Dutta describes how she—and her colleagues in the lab of Dr. Hans Clevers—infected intestinal and lung organoids derived from healthy human donors with Cryptosporidium. In their paper*, organoids are presented as a physiologically relevant in vitro model to study Cryptosporidium and other pathogenic infections.
SnapShot: Exercise Metabolism Overview on the skeletal muscle gene expression modulation, energy sources, and inter-organ communications during exercise
Travis Jackson Dr. Travis Jackson describes his research investigating cell signaling mechanisms contributing to neuronal or axonal injury
Wardiya Saber Dr. Wardiya Afshar Saber describes her work examining synaptic activity in Alzheimer’s disease using optogenetics and stem cell technology
Jürgen Knoblich, PhD Dr. Knoblich describes his work using organoids to understand mechanisms of human brain development
Supplementary Protocols for IntestiCult™ Organoid Growth Medium (Human) Protocols for the differentiation of human intestinal organoids, growth as a monolayer culture, and cryopreservation and thawing protocols for long-term storage.
Organoid Expert Panel What could organoids do for your research? In this in-depth panel discussion, STEMCELL's organoid experts answer questions submitted by you. Topics include evaluating organoids as tissue and disease models, variability in organoid cultures, and future outlooks in translational and clinical applications.
