Applications of Human Intestinal Organoid Cultures in Drug Discovery
Human intestinal organoids provide a scalable and highly predictive model system for studying the effects of novel therapeutics in vitro. Intestinal organoids contain the relevant cell types that constitute the intestinal epithelium and, as such, can be maintained in various states of proliferation or differentiation. These physiologically relevant models reveal the toxicity of compounds that can not be seen in Caco-2 cells, which are frequently used to model the intestine during drug development programs.
In this webinar, Danny Leung and Dr. Victoria Conlin from STEMCELL Technologies describe, in detail, what intestinal organoids are, how they mimic the immunocytochemistry and morphology of the human gut epithelium, and how to use organoids for drug screening. They also discuss the intestinal organoid assays offered by Contract Assay Services (CAS) at STEMCELL Technologies.
Predictive In Vitro Models for Toxicity Testing and Liver Research
Having validated tools to perform predictive assays in a biologically-relevant system is key to success in drug discovery research. In this webinar, Dr. Terry Riss (Promega Corp) and Jennifer Christie (STEMCELL Technologies) discuss products and protocols that enable the incorporation of validated in vitro alternatives to animal models for toxicology studies. First, Dr. Riss presents in vitro assays for 3D cultures that monitor drug-induced cytotoxicity and explains how different assays can be multiplexed to measure multiple cell health parameters. Following this, Ms. Christie describes how to generate mature and functional hepatic organoids using HepatiCult™ and demonstrates their applications in liver research and hepatotoxicity assessment.
EasySep™小鼠TIL（CD45）正选试剂盒
Applications of Human Intestinal Organoid Cultures in Drug Discovery Human intestinal organoids provide a scalable and highly predictive model system for studying the effects of novel therapeutics in vitro. Intestinal organoids contain the relevant cell types that constitute the intestinal epithelium and, as such, can be maintained in various states of proliferation or differentiation. These physiologically relevant models reveal the toxicity of compounds that can not be seen in Caco-2 cells, which are frequently used to model the intestine during drug development programs.
Predictive In Vitro Models for Toxicity Testing and Liver Research Having validated tools to perform predictive assays in a biologically-relevant system is key to success in drug discovery research. In this webinar, Dr. Terry Riss (Promega Corp) and Jennifer Christie (STEMCELL Technologies) discuss products and protocols that enable the incorporation of validated in vitro alternatives to animal models for toxicology studies. First, Dr. Riss presents in vitro assays for 3D cultures that monitor drug-induced cytotoxicity and explains how different assays can be multiplexed to measure multiple cell health parameters. Following this, Ms. Christie describes how to generate mature and functional hepatic organoids using HepatiCult™ and demonstrates their applications in liver research and hepatotoxicity assessment.
